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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-10-26
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pubmed:abstractText |
The effects of 6,7,8, 9-tetrahydro-2-methyl-5H-cyclohepta[b]pyridine-3-carbonylguanidine maleate (TY-12533) on myocardial ischemia/reperfusion injury were evaluated in rats. Inhibitory effects of TY-12533, TY-50893 (the 9-chloro derivative of TY-12533) and cariporide on the platelet Na(+)/H(+) exchanger in vitro were almost equal at pH 6.2 and decreased at pH 6.7; but TY-12533 was four times more potent than TY-50893 and cariporide at pH 6.7. TY-12533, TY-50893 and cariporide administered before ischemia (0.01-1 mg/kg, i.v.) suppressed the ischemia/reperfusion-induced arrhythmias to the same extent in vivo; but TY-12533 was more effective than cariporide and TY-50893 when they were administered during ischemia (0.1-1 mg/kg). Similar results were obtained for the inhibitory effects of these drugs administered before ischemia (0.03-0.1 mg/kg, i.v.) and during ischemia (0.1-1 mg/kg) on the ischemia/reperfusion-induced myocardial infarction. These differences between TY-12533 and the other drugs in vitro and in vivo may be ascribed to the pK(a) values of the guanidinium moiety of TY-12533 (6.93), TY-50893 (6.35) and cariporide (6.28).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-2999
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pubmed:author |
pubmed-author:AiharaKK,
pubmed-author:HirtDD,
pubmed-author:KimuraTT,
pubmed-author:KogiKK,
pubmed-author:MizunoYY,
pubmed-author:NagaiAA,
pubmed-author:SasamoriJJ,
pubmed-author:SatoTT,
pubmed-author:SatohSS,
pubmed-author:TakahashiAA,
pubmed-author:YamaguchiFF,
pubmed-author:YoneyamaFF,
pubmed-author:YoneyamaSS
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
404
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10980282-Aconitine,
pubmed-meshheading:10980282-Animals,
pubmed-meshheading:10980282-Anti-Arrhythmia Agents,
pubmed-meshheading:10980282-Arrhythmias, Cardiac,
pubmed-meshheading:10980282-Cardiotonic Agents,
pubmed-meshheading:10980282-Disease Models, Animal,
pubmed-meshheading:10980282-Guanidines,
pubmed-meshheading:10980282-Male,
pubmed-meshheading:10980282-Myocardial Infarction,
pubmed-meshheading:10980282-Myocardial Ischemia,
pubmed-meshheading:10980282-Myocardial Reperfusion Injury,
pubmed-meshheading:10980282-Pyridines,
pubmed-meshheading:10980282-Rats,
pubmed-meshheading:10980282-Rats, Wistar,
pubmed-meshheading:10980282-Sodium-Hydrogen Antiporter,
pubmed-meshheading:10980282-Sulfones
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pubmed:year |
2000
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pubmed:articleTitle |
Cardioprotective effect of TY-12533, a novel Na(+)/H(+) exchange inhibitor, on ischemia/reperfusion injury.
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pubmed:affiliation |
Laboratory of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, 980-8578, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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