|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0027893,
umls-concept:C0030685,
umls-concept:C0031511,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0043481,
umls-concept:C0127400,
umls-concept:C0332291,
umls-concept:C0391871,
umls-concept:C0441712,
umls-concept:C0441889,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
2000-11-28
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pubmed:abstractText |
Both zinc and neuropeptide Y (NPY) have been implicated as playing a role in seizures and feeding behavior. We investigated the hypothesis that zinc could regulate levels of NPY, and found that chronic exposure to 50-100 microM zinc increased levels of cellular NPY in cultured PC12 cells grown in the presence of nerve growth factor. Zinc's effect on NPY was specific, time- and concentration-dependent, and independent of inhibition of NPY release secondary to blockade of dihydropyridine-sensitive calcium channels. These results are consistent with a role for zinc in regulating hippocampal NPY following high-frequency neuronal activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-8993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
877
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Zinc elevates neuropeptide Y levels in rat pheochromocytoma cells by a mechanism independent of L-channel mediated inhibition of release.
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pubmed:affiliation |
Department of Biology, Williams College, Bronfman Science Center, 18 Hoxsey Street, Williamstown, MA, 01267, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
