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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
Chimpanzees are susceptible to infection with human immunodeficiency virus (HIV)-1; however, infected animals usually maintain normal numbers of CD4(+) T lymphocytes and do not develop immunodeficiency. We have examined 10 chronically infected HIV-1-positive chimpanzees for evidence of progressive infection. In addition to 1 animal that developed AIDS, 3 chimpanzees exhibit evidence of progressive HIV infection. All progressors have low CD4(+) T cell counts (<200 cells/microL), severe CD4:CD8 inversion, and marked reduction in interleukin-2 receptor expression by CD4(+) T cells. In comparison with HIV-positive nonprogressor chimpanzees, progressors have higher plasma and lymphoid virus loads, greater CD38 expression in CD8(+)/HLA-DR(+) T cells, and greater serum concentrations of soluble tumor necrosis factor type II receptors and beta2-microglobulin, all markers of HIV progression in humans. These observations show that progressive HIV-1 infection can occur in chimpanzees and suggest that the pathogenesis of progressive infection in this species resembles that in humans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:AndersonD CDC,
pubmed-author:Evans-StrickfadenTT,
pubmed-author:HartC ECE,
pubmed-author:HerndonJ GJG,
pubmed-author:HillA BAB,
pubmed-author:McClureH MHM,
pubmed-author:NovembreF JFJ,
pubmed-author:O'NeilS PSP,
pubmed-author:SaucierMM,
pubmed-author:SuwynCC,
pubmed-author:deRosayroJJ
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pubmed:issnType |
Print
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1051-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10979899-ADP-ribosyl Cyclase,
pubmed-meshheading:10979899-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10979899-Animals,
pubmed-meshheading:10979899-Antigens, CD,
pubmed-meshheading:10979899-Antigens, CD29,
pubmed-meshheading:10979899-Antigens, CD38,
pubmed-meshheading:10979899-Antigens, Differentiation,
pubmed-meshheading:10979899-CD4 Lymphocyte Count,
pubmed-meshheading:10979899-CD4-CD8 Ratio,
pubmed-meshheading:10979899-Disease Progression,
pubmed-meshheading:10979899-Female,
pubmed-meshheading:10979899-HIV Infections,
pubmed-meshheading:10979899-HIV Seropositivity,
pubmed-meshheading:10979899-HLA-DR Antigens,
pubmed-meshheading:10979899-Humans,
pubmed-meshheading:10979899-Lymph Nodes,
pubmed-meshheading:10979899-Lymphocyte Subsets,
pubmed-meshheading:10979899-Male,
pubmed-meshheading:10979899-Membrane Glycoproteins,
pubmed-meshheading:10979899-NAD+ Nucleosidase,
pubmed-meshheading:10979899-Pan troglodytes,
pubmed-meshheading:10979899-Receptors, Interleukin-2,
pubmed-meshheading:10979899-T-Lymphocytes,
pubmed-meshheading:10979899-Time Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Progressive infection in a subset of HIV-1-positive chimpanzees.
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pubmed:affiliation |
Yerkes Regional Primate Research Center, Atlanta, GA 30329, USA. soneil@rmy.emory.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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