Linked Life Data

10978588

Source:http://linkedlifedata.com/resource/pubmed/id/10978588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-10-17
pubmed:abstractText
The localization and function of aryl hydrocarbon receptor nuclear translocator (ARNT) in the brain are still unclear. In this study, we examined changes of ARNT protein in rat hippocampus, by immunoblotting and immunohistochemical analysis using anti-ARNT antibody. Treatment of kainic acid (KA) induced marked increase in ARNT protein in both cytosolic and organellar fractions. ARNT immunoreactivity was markedly increased, predominantly in microglia and partly in astrocytes, similar to the immunoreactivity of heme oxygenase-1. In contrast, protein level of dioxin receptor did not change and hypoxia-inducible factor-1alpha protein was undetectable. These results suggest that ARNT expression in glial cells may participate in KA-induced episodes in the hippocampus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
291
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Aryl hydrocarbon receptor nuclear translocator is induced by kainic acid in rat hippocampal glial cells.
pubmed:affiliation
Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, 607-8412, Kyoto, Japan. yo-kita@mb.kyoto-phu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't