| pubmed-article:10978576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0020944 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0010124 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:10978576 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:10978576 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10978576 | pubmed:dateCreated | 2000-10-17 | lld:pubmed |
| pubmed-article:10978576 | pubmed:abstractText | To evaluate the involvement of brain protein kinase C (PKC) in the stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis, we examined the effects of PKC inhibitors administered intracerebroventricularly (i.c.v.) on the immobilization stress-induced plasma corticosterone levels in mice. Calphostin C (a pan-specific PKC inhibitor) injected i.c.v. decreased the immobilization stress-induced plasma corticosterone level: maximal inhibition of 35% was attained at a dose of 100 pmol. Gö 6976 (an alpha and beta1 PKC isotype-selective inhibitor) was less effective than Calphostin C: maximal inhibition of 17% was attained at a dose of 30 pmol. Phorbol 12-myristate 13-acetate (a general PKC activator) injected i.c.v. at doses of 16 and 48 pmol increased the plasma corticosterone levels in a dose-dependent manner. The present study demonstrates the involvement of PKC in the brain in the regulation of the immobilization stress-induced stimulation of HPA axis in vivo. | lld:pubmed |
| pubmed-article:10978576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10978576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10978576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10978576 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10978576 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:KimY HYH | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:KimH SHS | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:KimD HDH | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:SuhH WHW | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:JungJ SJS | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:QuekC MCM | lld:pubmed |
| pubmed-article:10978576 | pubmed:author | pubmed-author:SonB KBK | lld:pubmed |
| pubmed-article:10978576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10978576 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10978576 | pubmed:volume | 291 | lld:pubmed |
| pubmed-article:10978576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10978576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10978576 | pubmed:pagination | 69-72 | lld:pubmed |
| pubmed-article:10978576 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10978576 | pubmed:meshHeading | pubmed-meshheading:10978576... | lld:pubmed |
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| pubmed-article:10978576 | pubmed:meshHeading | pubmed-meshheading:10978576... | lld:pubmed |
| pubmed-article:10978576 | pubmed:meshHeading | pubmed-meshheading:10978576... | lld:pubmed |
| pubmed-article:10978576 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10978576 | pubmed:articleTitle | Inhibition of brain protein kinase C attenuates immobilization stress-induced plasma corticosterone levels in mice. | lld:pubmed |
| pubmed-article:10978576 | pubmed:affiliation | Department of Psychiatry, College of Medicine, Hallym University, Chunchon, 200-702, Kangwon-Do, South Korea. | lld:pubmed |
| pubmed-article:10978576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10978576 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10978576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10978576 | lld:pubmed |
