Source:http://linkedlifedata.com/resource/pubmed/id/10978576
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-10-17
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pubmed:abstractText |
To evaluate the involvement of brain protein kinase C (PKC) in the stress-induced activation of hypothalamic-pituitary-adrenal (HPA) axis, we examined the effects of PKC inhibitors administered intracerebroventricularly (i.c.v.) on the immobilization stress-induced plasma corticosterone levels in mice. Calphostin C (a pan-specific PKC inhibitor) injected i.c.v. decreased the immobilization stress-induced plasma corticosterone level: maximal inhibition of 35% was attained at a dose of 100 pmol. Gö 6976 (an alpha and beta1 PKC isotype-selective inhibitor) was less effective than Calphostin C: maximal inhibition of 17% was attained at a dose of 30 pmol. Phorbol 12-myristate 13-acetate (a general PKC activator) injected i.c.v. at doses of 16 and 48 pmol increased the plasma corticosterone levels in a dose-dependent manner. The present study demonstrates the involvement of PKC in the brain in the regulation of the immobilization stress-induced stimulation of HPA axis in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Go 6976,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
291
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-72
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10978576-Animals,
pubmed-meshheading:10978576-Brain,
pubmed-meshheading:10978576-Carbazoles,
pubmed-meshheading:10978576-Corticosterone,
pubmed-meshheading:10978576-Enzyme Inhibitors,
pubmed-meshheading:10978576-Immobilization,
pubmed-meshheading:10978576-Indoles,
pubmed-meshheading:10978576-Injections, Intraventricular,
pubmed-meshheading:10978576-Mice,
pubmed-meshheading:10978576-Mice, Inbred ICR,
pubmed-meshheading:10978576-Naphthalenes,
pubmed-meshheading:10978576-Protein Kinase C,
pubmed-meshheading:10978576-Stress, Physiological
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pubmed:year |
2000
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pubmed:articleTitle |
Inhibition of brain protein kinase C attenuates immobilization stress-induced plasma corticosterone levels in mice.
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pubmed:affiliation |
Department of Psychiatry, College of Medicine, Hallym University, Chunchon, 200-702, Kangwon-Do, South Korea.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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