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rdf:type |
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lifeskim:mentions |
umls-concept:C0005117,
umls-concept:C0018270,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0038172,
umls-concept:C0070716,
umls-concept:C0332325,
umls-concept:C0449432,
umls-concept:C0912834,
umls-concept:C0949843,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1705920
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pubmed:issue |
8
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pubmed:dateCreated |
2000-10-31
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pubmed:abstractText |
A new method of bioactivity-directed fractionation, based on multidrug resistant pump (MDR) inhibition in Staphylococcus aureus, was demonstrated. This resulted in the isolation, from berberine-containing Berberis species, of two compounds that are themselves devoid of S. aureus antibacterial activity, but that form potent synergistic couples with a subinhibitory concentration of berberine. The bacterial MDR pump inhibitors were identified as the flavonolignan 2 and the porphyrin 3. Another natural flavonolignan, silybin (8) from Silybum marianum, was also shown to be a bacterial MDR pump inhibitor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1146-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10978214-Berberine,
pubmed-meshheading:10978214-Biological Assay,
pubmed-meshheading:10978214-Chlorophyll,
pubmed-meshheading:10978214-Chromatography, Gel,
pubmed-meshheading:10978214-Chromatography, Thin Layer,
pubmed-meshheading:10978214-Colorado,
pubmed-meshheading:10978214-Drug Resistance, Microbial,
pubmed-meshheading:10978214-Drug Resistance, Multiple,
pubmed-meshheading:10978214-Flavonoids,
pubmed-meshheading:10978214-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:10978214-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10978214-Microbial Sensitivity Tests,
pubmed-meshheading:10978214-Plant Leaves,
pubmed-meshheading:10978214-Plants, Medicinal,
pubmed-meshheading:10978214-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:10978214-Spectrophotometry, Ultraviolet,
pubmed-meshheading:10978214-Staphylococcus aureus
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pubmed:year |
2000
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pubmed:articleTitle |
5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus.
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pubmed:affiliation |
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, USA. frslab@lamar.colostate.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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