| pubmed-article:10975862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C0039099 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C1550315 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C1332823 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:10975862 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:10975862 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10975862 | pubmed:dateCreated | 2000-10-10 | lld:pubmed |
| pubmed-article:10975862 | pubmed:abstractText | Chemokines and their receptors determine the distribution of leukocytes within tissues in health and disease. We have studied the role of the constitutive chemokine receptor CXCR4 and its ligand, stromal-derived factor-1 (SDF-1) in the perivascular accumulation of T cells in rheumatoid arthritis. We show that synovial T cells, which are primed CD45RO+CD45RBdull cells and consequently not expected to express constitutive chemokine receptors, have high levels of the chemokine receptor CXCR4. Sustained expression of CXCR4 was maintained on synovial T cells by specific factors present within the synovial microenvironment. Extensive screening revealed that TGF-beta isoforms induce the expression of CXCR4 on CD4 T cells in vitro. Depletion studies using synovial fluid confirmed an important role for TGF-beta1 in the induction of CXCR4 expression in vivo. The only known ligand for CXCR4 is SDF-1. We found SDF-1 on synovial endothelial cells and showed that SDF-1 was able to induce strong integrin-mediated adhesion of synovial fluid T cells to fibronectin and ICAM-1, confirming that CXCR4 expressed on synovial T cells was functional. These results suggest that the persistent induction of CXCR4 on synovial T cells by TGF-beta1 leads to their active, SDF-1-mediated retention in a perivascular distribution within the rheumatoid synovium. | lld:pubmed |
| pubmed-article:10975862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10975862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10975862 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10975862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10975862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10975862 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10975862 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:RoseWW | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:AmareMM | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:LordJ MJM | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:SalmonMM | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:PillingDD | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:Arenzana-Seis... | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:CurnowS JSJ | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:BuckleyC DCD | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:Scheel-Toelln... | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:BOHMFF | lld:pubmed |
| pubmed-article:10975862 | pubmed:author | pubmed-author:BradfieldP... | lld:pubmed |
| pubmed-article:10975862 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10975862 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10975862 | pubmed:volume | 165 | lld:pubmed |
| pubmed-article:10975862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10975862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10975862 | pubmed:pagination | 3423-9 | lld:pubmed |
| pubmed-article:10975862 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10975862 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10975862 | pubmed:articleTitle | Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. | lld:pubmed |
| pubmed-article:10975862 | pubmed:affiliation | Division of Immunity and Infection, Medical Research Council Center for Immune Regulation, University of Birmingham, Edgbaston, United Kingdom. c.d.buckley@bham.ac.uk | lld:pubmed |
| pubmed-article:10975862 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10975862 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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