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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0376315,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0913092,
umls-concept:C1414549,
umls-concept:C1520840,
umls-concept:C1539099,
umls-concept:C1552599,
umls-concept:C1704332,
umls-concept:C1704787
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pubmed:issue |
6
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pubmed:dateCreated |
2000-10-10
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pubmed:databankReference |
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pubmed:abstractText |
DC-SIGN is a C-type lectin, expressed on a dendritic cell subset. It is able to bind ICAM3 and HIV gp120 in a calcium-dependent manner. Here we report the genomic organization of DC-SIGN and map it to chromosome 19p13 adjacent to the C-type lectin CD23 (FcepsilonRII). We also report a novel, closely linked gene, DC-SIGNR, which shows 73% identity to DC-SIGN at the nucleic acid level and a similar genomic organization. Proteins encoded by both genes have tracts of repeats of 23 aa, predicted to form a coiled coil neck region. They also possess motifs that are known to bind mannose in a calcium-dependent fashion. We show concomitant expression of the two genes in endometrium, placenta, and stimulated KG1 cells (phenotypically similar to monocyte-derived dendritic cells). The existence of a DC-SIGN-related gene calls for reinterpretation of the HIV data to consider possible DC-SIGN/DC-SIGNR hetero-oligomerization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2937-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10975799-Amino Acid Sequence,
pubmed-meshheading:10975799-Cell Adhesion Molecules,
pubmed-meshheading:10975799-Cell Line,
pubmed-meshheading:10975799-Chromosome Mapping,
pubmed-meshheading:10975799-Chromosomes, Human, Pair 19,
pubmed-meshheading:10975799-Cloning, Molecular,
pubmed-meshheading:10975799-DNA, Complementary,
pubmed-meshheading:10975799-Dendritic Cells,
pubmed-meshheading:10975799-Exons,
pubmed-meshheading:10975799-Gene Expression,
pubmed-meshheading:10975799-Genetic Linkage,
pubmed-meshheading:10975799-Humans,
pubmed-meshheading:10975799-Introns,
pubmed-meshheading:10975799-Lectins,
pubmed-meshheading:10975799-Lectins, C-Type,
pubmed-meshheading:10975799-Molecular Sequence Data,
pubmed-meshheading:10975799-Multigene Family,
pubmed-meshheading:10975799-Organ Specificity,
pubmed-meshheading:10975799-Receptors, Cell Surface,
pubmed-meshheading:10975799-Receptors, IgE,
pubmed-meshheading:10975799-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2000
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pubmed:articleTitle |
DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.
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pubmed:affiliation |
Immunology, Department of Pathology, Cambridge University, United Kingdom. ejs17@mole.bio.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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