Source:http://linkedlifedata.com/resource/pubmed/id/10975477
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2000-12-11
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| pubmed:abstractText |
Intracellular cytokine staining and flow cytometry were used to investigate whether immunoadsorption (IA) of immunoglobulins alters intracytoplasmic cytokine production in CD4+ and CD8+ T cells from the blood of patients with refractory rheumatoid arthritis (n = 7), membrane proliferative glomerulonephritis (n = 1), and Goodpasture's syndrome (n = 1). Four patients (Group 1) showed severely depressed production of TNF-alpha, IL-2, IFN-gamma, and IL-4 by CD4+ and CD8+ T cells and responded to 3 IA sessions with significant increases in CD4+TNF-alpha+, CD4+IL-2+, and CD8+IL-2+ T cells. Also, a tendency toward increased percentage levels of CD4+ T cells producing IFN-gamma or IL-4 and of CD8+ T cells producing either TNF-alpha or IFN-gamma was seen, but due to the small number of patients investigated, these differences did not attain statistic significance. Group 2 (n = 5) showed unimpaired intracellular cytokine levels and responded to IA with a heterogeneous pattern of changes in TNF-alpha, IL-2, IFN-gamma, and IL-4 production, but these alterations were smaller than those in Group 1. The present findings indicate that the extracorporeal removal of immunoglobulins by anti-IgG or protein A adsorber columns has an impact on T cell immunity and suggest that modulating effects on cellular immune system function are involved in the mode of action of IA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1091-6660
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
4
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
296-302
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:10975477-Adult,
pubmed-meshheading:10975477-Anti-Glomerular Basement Membrane Disease,
pubmed-meshheading:10975477-Arthritis, Rheumatoid,
pubmed-meshheading:10975477-Autoimmune Diseases,
pubmed-meshheading:10975477-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10975477-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10975477-Cytokines,
pubmed-meshheading:10975477-Female,
pubmed-meshheading:10975477-Flow Cytometry,
pubmed-meshheading:10975477-Glomerulonephritis, Membranous,
pubmed-meshheading:10975477-Humans,
pubmed-meshheading:10975477-Immunoglobulin G,
pubmed-meshheading:10975477-Immunosorbent Techniques,
pubmed-meshheading:10975477-Interferon-gamma,
pubmed-meshheading:10975477-Interleukin-2,
pubmed-meshheading:10975477-Interleukin-4,
pubmed-meshheading:10975477-Male,
pubmed-meshheading:10975477-Middle Aged,
pubmed-meshheading:10975477-Plasmapheresis,
pubmed-meshheading:10975477-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Immunoadsorption of immunoglobulins alters intracytoplasmic type 1 and type 2 T cell cytokine production in patients with refractory autoimmune diseases.
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| pubmed:affiliation |
Institute of Diabetes Gerhardt Katsch Karlsburg, Germany.
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| pubmed:publicationType |
Journal Article
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