|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0018067,
umls-concept:C0033684,
umls-concept:C0162610,
umls-concept:C0205314,
umls-concept:C0679622,
umls-concept:C0815089,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1551336,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C2331667,
umls-concept:C2700640
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2000-10-16
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The Caenorhabditis elegans gene lin-9 functions in an Rb-related pathway that acts antagonistically to a receptor tyrosine kinase/Ras signal transduction pathway controlling vulval induction. We show that lin-9 is also required for the development of the sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. lin-9 is transcribed as two alternatively spliced 2.4kb messages, which use two distinct polyadenylation sites and are SL1 trans-spliced. The conceptual translation of lin-9 cDNA sequences predicts proteins of 642 and 644 amino acids with a significant similarity to predicted Drosophila and vertebrate proteins. We suggest that lin-9 is the founding member of a new protein family that functions in Rb-related pathways in many species.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0378-1119
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
22
|
|
pubmed:volume |
254
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
253-63
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:10974557-Alternative Splicing,
pubmed-meshheading:10974557-Amino Acid Sequence,
pubmed-meshheading:10974557-Animals,
pubmed-meshheading:10974557-Animals, Genetically Modified,
pubmed-meshheading:10974557-Base Sequence,
pubmed-meshheading:10974557-Caenorhabditis elegans,
pubmed-meshheading:10974557-Caenorhabditis elegans Proteins,
pubmed-meshheading:10974557-Cloning, Molecular,
pubmed-meshheading:10974557-DNA, Complementary,
pubmed-meshheading:10974557-Disorders of Sex Development,
pubmed-meshheading:10974557-Female,
pubmed-meshheading:10974557-Genes, Helminth,
pubmed-meshheading:10974557-Genetic Complementation Test,
pubmed-meshheading:10974557-Gonads,
pubmed-meshheading:10974557-Helminth Proteins,
pubmed-meshheading:10974557-Male,
pubmed-meshheading:10974557-Molecular Sequence Data,
pubmed-meshheading:10974557-Nucleic Acid Hybridization,
pubmed-meshheading:10974557-Phenotype,
pubmed-meshheading:10974557-Point Mutation,
pubmed-meshheading:10974557-RNA, Helminth,
pubmed-meshheading:10974557-Retinoblastoma Protein,
pubmed-meshheading:10974557-Sequence Analysis, DNA,
pubmed-meshheading:10974557-Sequence Homology, Amino Acid,
pubmed-meshheading:10974557-Transcription, Genetic
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
