| pubmed-article:10974349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10974349 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10974349 | lifeskim:mentions | umls-concept:C0032140 | lld:lifeskim |
| pubmed-article:10974349 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10974349 | lifeskim:mentions | umls-concept:C0060794 | lld:lifeskim |
| pubmed-article:10974349 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:10974349 | pubmed:dateCreated | 2000-12-7 | lld:pubmed |
| pubmed-article:10974349 | pubmed:abstractText | The effect of an anticoagulant fucoidan (C-I-H) from the brown seaweed Ecklonia kurome on the fibrinolytic system was studied in vitro using S-2251 as a substrate of plasmin. C-I-H enhanced the activation of Glu- and Lys-plasminogen by high molecular weight urokinase-type plasminogen activator (HMW u-PA) very effectively, but the activation by low molecular weight u-PA was hardly enhanced with C-I-H. C-I-H also potentiated moderately the activation by single- and two-chain tissue-type plasminogen activators (sct- and tct-PA). These effects of C-I-H were higher than those of heparin used. But C-I-H had no effect on the amidolytic activity of plasmin to S-2251. These results indicate that C-I-H promotes the generation of plasmin in the plasminogen activation by HMW u-PA and t-PA, but not the activity of generated plasmin. Kinetic analyses suggest that C-I-H enhances the HMW u-PA-mediated plasminogen activation by increasing the affinity of the activator for Glu- and Lys-plasminogen and by increasing the molecular activity of the activator. On the other hand, C-I-H had no effect on the affinity of tct-PA for both plasminogens. The catalytic efficiencies of HMW u-PA and tct-PA for the activation of both plasminogens were increased with C-I-H about 8- and 2-fold, respectively. The present results suggest that C-I-H has the fibrinolytic activity by stimulating the plasminogen activation by HMW u-PA and t-PA. The mechanism of the enhancement effect of C-I-H on the activation is presumed to be that C-I-H binds to plasminogen, thereby inducing a structural change of plasminogen susceptible to the action of plasminogen activators. | lld:pubmed |
| pubmed-article:10974349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10974349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10974349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10974349 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10974349 | pubmed:issn | 0049-3848 | lld:pubmed |
| pubmed-article:10974349 | pubmed:author | pubmed-author:YamauchiTT | lld:pubmed |
| pubmed-article:10974349 | pubmed:author | pubmed-author:SuzukiHH | lld:pubmed |
| pubmed-article:10974349 | pubmed:author | pubmed-author:NishinoTT | lld:pubmed |
| pubmed-article:10974349 | pubmed:author | pubmed-author:NagumoTT | lld:pubmed |
| pubmed-article:10974349 | pubmed:author | pubmed-author:HorieMM | lld:pubmed |
| pubmed-article:10974349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10974349 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:10974349 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:10974349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10974349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10974349 | pubmed:pagination | 623-34 | lld:pubmed |
| pubmed-article:10974349 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:10974349 | pubmed:meshHeading | pubmed-meshheading:10974349... | lld:pubmed |
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| pubmed-article:10974349 | pubmed:meshHeading | pubmed-meshheading:10974349... | lld:pubmed |
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| pubmed-article:10974349 | pubmed:meshHeading | pubmed-meshheading:10974349... | lld:pubmed |
| pubmed-article:10974349 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10974349 | pubmed:articleTitle | Effects of a fucoidan on the activation of plasminogen by u-PA and t-PA. | lld:pubmed |
| pubmed-article:10974349 | pubmed:affiliation | Department of Biosciences, School of Science, Sagamihara, Kitasato, Japan. nisino@jet.sci.kitasato-u.ac.jp | lld:pubmed |
| pubmed-article:10974349 | pubmed:publicationType | Journal Article | lld:pubmed |
