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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-9-28
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pubmed:abstractText |
The aged appearance of skin following repeated exposure to solar ultraviolet (UV) irradiation stems largely from damage to cutaneous connective tissue, which is composed primarily of type I and type III collagens. We report here that a single exposure to UV irradiation causes significant loss of procollagen synthesis in human skin. Expression of type I and type III procollagens is substantially reduced within 24 hours after a single UV exposure, even at UV doses that cause only minimal skin reddening. Daily UV exposures over 4 days result in sustained reductions of both type I and type III procollagen protein levels for at least 24 hours after the final UV exposure. UV inhibition of type I procollagen synthesis is mediated in part by c-Jun, which is induced by UV irradiation and interferes with procollagen transcription. Pretreatment of human skin in vivo with all-trans retinoic acid inhibits UV induction of c-Jun and protects skin against loss of procollagen synthesis. We have reported previously that UV irradiation induces matrix-degrading metalloproteinases in human skin and that pretreatment of skin with all-trans retinoic acid inhibits this induction. UV irradiation, therefore, damages human skin connective tissue by simultaneously inhibiting procollagen synthesis and stimulating collagen breakdown. All-trans retinoic acid protects against both of these deleterious effects and may thereby retard premature skin aging.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1673698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1728634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1732386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1732390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1919057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-1985542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-2500439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-2519621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-3099780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-3397590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-434832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-5395389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-6418743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7543550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7615982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7690546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7721853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7790374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7852421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-7876190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8051161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8108121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8175678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8310007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8336752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8552187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8621730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8642084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8783182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-8900150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-9305936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-9358139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10974019-9502786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10974019-Dose-Response Relationship, Radiation,
pubmed-meshheading:10974019-European Continental Ancestry Group,
pubmed-meshheading:10974019-Female,
pubmed-meshheading:10974019-Gene Expression Regulation,
pubmed-meshheading:10974019-Humans,
pubmed-meshheading:10974019-In Situ Hybridization,
pubmed-meshheading:10974019-Male,
pubmed-meshheading:10974019-Procollagen,
pubmed-meshheading:10974019-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:10974019-Radiation-Protective Agents,
pubmed-meshheading:10974019-Skin,
pubmed-meshheading:10974019-Skin Aging,
pubmed-meshheading:10974019-Transcription, Genetic,
pubmed-meshheading:10974019-Tretinoin,
pubmed-meshheading:10974019-Ultraviolet Rays
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pubmed:year |
2000
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pubmed:articleTitle |
c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid.
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pubmed:affiliation |
Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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