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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1975-11-6
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pubmed:abstractText |
Genetic analysis of venturicidin-resistant mutants has revealed the presence of both nuclear and mitochondrial genes responsible for determining venturicidin sensitivity/resistance in Saccharomyces cerevisiae. Recombination studies show that the mutation with phenotype VENR is situated at mitochondrial locus OL I and is therefore extremely useful of future genetic manipulations as it gives a unique phenotype to this locus distinguishable from the second oligomycin locus OL II. The mutations with phenotype VENR OLYR are linked to oligomycin locus OL I and have been allocated a new mitochondrial locus, namely OL III. Three factor croses involving the venturicidin mutations at loci OL I and OL III have shown them to freely recombine with the other mitochondrial loci R I, R III and OL II. The mitochondrial genetic map is therefore represented as four 'recombinational linkage groups'. A fifth linkage group is also specified for mutants with phenotype VENR TETR, and is probably located on a separate DNA molecule from the four other groups.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2956
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1097243-Antifungal Agents,
pubmed-meshheading:1097243-Chromosome Mapping,
pubmed-meshheading:1097243-Crosses, Genetic,
pubmed-meshheading:1097243-Drug Resistance, Microbial,
pubmed-meshheading:1097243-Ethidium,
pubmed-meshheading:1097243-Genetic Linkage,
pubmed-meshheading:1097243-Lactones,
pubmed-meshheading:1097243-Mitochondria,
pubmed-meshheading:1097243-Mutation,
pubmed-meshheading:1097243-Oligomycins,
pubmed-meshheading:1097243-Oxidative Phosphorylation,
pubmed-meshheading:1097243-Phenotype,
pubmed-meshheading:1097243-Recombination, Genetic,
pubmed-meshheading:1097243-Saccharomyces cerevisiae,
pubmed-meshheading:1097243-Species Specificity
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pubmed:year |
1975
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pubmed:articleTitle |
Studies on energy-linked reactions: genetic analysis of venturicidin-resistant mutants.
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pubmed:publicationType |
Journal Article
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