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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2000-11-7
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pubmed:abstractText |
The mammalian target of rapamycin (mTOR) belongs to the family of phosphoinositide (PI)-kinase-related kinases that includes the ataxia-telangiectasia gene product (ATM). mTOR plays a critical role in controlling translational effectors such as p70 S6 kinase alpha (p70 alpha) and eukaryotic initiation factor 4E binding protein 1 (4EBP1).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1356-9597
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
765-75
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10971657-Amino Acid Sequence,
pubmed-meshheading:10971657-Cell Line,
pubmed-meshheading:10971657-Conserved Sequence,
pubmed-meshheading:10971657-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:10971657-Humans,
pubmed-meshheading:10971657-Molecular Sequence Data,
pubmed-meshheading:10971657-Mutagenesis, Site-Directed,
pubmed-meshheading:10971657-Peptide Initiation Factors,
pubmed-meshheading:10971657-Phosphorylation,
pubmed-meshheading:10971657-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:10971657-Protein Kinases,
pubmed-meshheading:10971657-Ribosomal Protein S6 Kinases,
pubmed-meshheading:10971657-Sequence Alignment,
pubmed-meshheading:10971657-Sequence Deletion,
pubmed-meshheading:10971657-Sirolimus,
pubmed-meshheading:10971657-TOR Serine-Threonine Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro.
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pubmed:affiliation |
Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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