Source:http://linkedlifedata.com/resource/pubmed/id/10971401
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-10-2
|
| pubmed:abstractText |
We report a case of congenital dyserythropoietic anaemia, type I, with severe pre- and postnatal manifestations. Exchange transfusions were required for fetal anaemia (3.5 g/dl) at 28 and 30 weeks of gestation. Transfusions were administered at birth (Caesarean section at week 35) and at regular intervals thereafter. At 14 months, alpha-interferon therapy was initiated (106 units three times a week). This resulted in stabilization of the haemoglobin at or above 11 g/dl and a reduction in the percentage of erythroblasts with ultrastructurally abnormal heterochromatin. After 9 months, the dose of alpha-interferon was decreased to 106 units twice a week. No relapse of anaemia was noted during an additional 4 months of follow-up.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
110
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
420-3
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10971401-Adult,
pubmed-meshheading:10971401-Anemia, Dyserythropoietic, Congenital,
pubmed-meshheading:10971401-Bone Marrow Examination,
pubmed-meshheading:10971401-Exchange Transfusion, Whole Blood,
pubmed-meshheading:10971401-Female,
pubmed-meshheading:10971401-Humans,
pubmed-meshheading:10971401-Infant,
pubmed-meshheading:10971401-Infant, Newborn,
pubmed-meshheading:10971401-Interferon-alpha,
pubmed-meshheading:10971401-Iron Overload,
pubmed-meshheading:10971401-Liver Function Tests,
pubmed-meshheading:10971401-Pregnancy,
pubmed-meshheading:10971401-Pregnancy Trimester, Second,
pubmed-meshheading:10971401-Pregnancy Trimester, Third,
pubmed-meshheading:10971401-Prenatal Diagnosis,
pubmed-meshheading:10971401-Recombinant Proteins,
pubmed-meshheading:10971401-Treatment Outcome
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Severe congenital dyserythropoietic anaemia type I: prenatal management, transfusion support and alpha-interferon therapy.
|
| pubmed:affiliation |
Service de Pédiatrie Générale, Hôpital de Bicêtre, AP-HP, et Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|