|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005863,
umls-concept:C0007745,
umls-concept:C0010453,
umls-concept:C0022567,
umls-concept:C0037907,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0301630,
umls-concept:C0332281,
umls-concept:C0441889,
umls-concept:C0597712
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|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2000-10-24
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|
pubmed:abstractText |
Ceramides produced by sphingomyelin hydrolysis activate a cycle that is followed by three different major cellular responses: downregulation of cell proliferation, induction of cell differentiation and apoptosis. In the skin, the generation of intracellular ceramide may also provide a link between an extracellular signal and the induction of the apoptosis programme for the elimination of damaged cells.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0007-0963
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
143
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
491-7
|
|
pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:10971319-Apoptosis,
pubmed-meshheading:10971319-Blotting, Western,
pubmed-meshheading:10971319-Cell Count,
pubmed-meshheading:10971319-Cell Division,
pubmed-meshheading:10971319-Cells, Cultured,
pubmed-meshheading:10971319-Culture Media, Serum-Free,
pubmed-meshheading:10971319-Dose-Response Relationship, Drug,
pubmed-meshheading:10971319-Down-Regulation,
pubmed-meshheading:10971319-Flow Cytometry,
pubmed-meshheading:10971319-Humans,
pubmed-meshheading:10971319-In Situ Nick-End Labeling,
pubmed-meshheading:10971319-Infant, Newborn,
pubmed-meshheading:10971319-Keratinocytes,
pubmed-meshheading:10971319-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:10971319-Sphingosine
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes.
|
|
pubmed:affiliation |
Departments of Dermatology and Biomedical Sciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy. anndinar@tin.it
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pubmed:publicationType |
Journal Article
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