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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2000-10-24
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pubmed:abstractText |
The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function. We now show that mice expressing active lck(F505) at non-oncogenic levels develop aggressive thymic lymphomas on a CD45(-/-) background. CD45 suppresses the tumorigenic potential of the kinase by dephosphorylation of the Tyr394 autophosphorylation site. In CD45(-/-) thymocytes the kinase is switched to a hyperactive oncogenic state, resulting in increased resistance to apoptosis. Transformation occurs in early CD4(-)CD8(-) thymocytes during the process of TCR-beta chain rearrangement by a recombinase-independent mechanism. Our findings represent the first example in which a tyrosine phosphatase in situ prevents the oncogenic actions of a SRC: family tyrosine kinase.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10330160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10367899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10375547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10377173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10415030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10435582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10458749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10462740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10462741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10473096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-10508267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1324691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1334460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1464315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1531305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1708890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-1709675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-2164155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-2530588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-2550143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-7592753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-7889413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-7926785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8011300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8139546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8168490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8175795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8334701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8413611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8433999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8441403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8642247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8666928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8666950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8706129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-8756658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9040011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9143695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9166833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9174406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9190928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9191133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9325251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9419216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9486849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9504632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9584189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9646843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9727489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9820525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10970857-9973453
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4644-54
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10970857-Animals,
pubmed-meshheading:10970857-Mice,
pubmed-meshheading:10970857-Mutation,
pubmed-meshheading:10970857-Thymus Neoplasms,
pubmed-meshheading:10970857-Lymphoma, Non-Hodgkin,
pubmed-meshheading:10970857-Base Sequence,
pubmed-meshheading:10970857-Tumor Cells, Cultured,
pubmed-meshheading:10970857-DNA Nucleotidyltransferases,
pubmed-meshheading:10970857-Apoptosis,
pubmed-meshheading:10970857-Mice, Mutant Strains
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