| pubmed-article:10970768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10970768 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10970768 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10970768 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:10970768 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:10970768 | lifeskim:mentions | umls-concept:C0600431 | lld:lifeskim |
| pubmed-article:10970768 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10970768 | pubmed:dateCreated | 2000-11-29 | lld:pubmed |
| pubmed-article:10970768 | pubmed:abstractText | The roles of P(2X1)and P(2T AC)receptors in ADP-evoked Ca(2+)signalling were investigated in fura-2-loaded human platelets. Desensitization of the P(2X1)receptor with the selective agonist, alphabeta-methylene ATP, reduced the integral of the ADP-evoked rise in [Ca(2+)](i)to about 90% of control; a reduction equivalent to the integral of the P(2X1)-evoked response alone. After elevating cAMP or cGMP levels using prostaglandin E(1)or sodium nitroprusside, prior P(2X1)desensitization reduced the integral of the ADP-evoked response to about 70% of control. This reduction was greater than the integral of the P(2X1)-evoked response alone under the same conditions, suggesting rapidly activated Ca(2+)entry via the P(2X1)receptor potentiates Ca(2+)responses evoked via the phospholipase C-coupled P(2Y1)receptor. The P(2T AC)receptor antagonist, AR-C69931MX, at a concentration completely inhibiting aggregation, did not significantly affect the initial peaks but caused a significant reduction in the integrals of the ADP-evoked rises in [Ca(2+)](i)to about 71% or 77% of controls in the presence or absence of external Ca(2+)respectively. This suggests that the main effect of lowering cAMP levels after inhibition of adenylyl cyclase via P(2T AC)receptors may be reduced Ca(2+)removal from the cytosol. These results indicate that both the P(2X1)and P(2T AC)receptors play a significant role in ADP-evoked Ca(2+)signalling in human platelets. | lld:pubmed |
| pubmed-article:10970768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10970768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10970768 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10970768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10970768 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10970768 | pubmed:issn | 0143-4160 | lld:pubmed |
| pubmed-article:10970768 | pubmed:author | pubmed-author:SageS OSO | lld:pubmed |
| pubmed-article:10970768 | pubmed:author | pubmed-author:HeemskerkJ... | lld:pubmed |
| pubmed-article:10970768 | pubmed:author | pubmed-author:YamoahE HEH | lld:pubmed |
| pubmed-article:10970768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10970768 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:10970768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10970768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10970768 | pubmed:pagination | 119-26 | lld:pubmed |
| pubmed-article:10970768 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10970768 | pubmed:meshHeading | pubmed-meshheading:10970768... | lld:pubmed |
| pubmed-article:10970768 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10970768 | pubmed:articleTitle | The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets. | lld:pubmed |
| pubmed-article:10970768 | pubmed:affiliation | Department of Physiology, University of Cambridge, Cambridge, UK. sos10@cam.ac.uk | lld:pubmed |
| pubmed-article:10970768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10970768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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