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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2000-12-6
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pubmed:abstractText |
A series of novel C2-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) has been synthesised via a versatile pro-C2 ketone precursor. C2-exo-unsaturation enhances both DNA-binding reactivity and in vitro cytotoxic potency.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
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pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
21
|
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pubmed:volume |
10
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1845-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10969982-Animals,
pubmed-meshheading:10969982-Antibiotics, Antineoplastic,
pubmed-meshheading:10969982-Benzodiazepines,
pubmed-meshheading:10969982-Benzodiazepinones,
pubmed-meshheading:10969982-DNA,
pubmed-meshheading:10969982-Drug Screening Assays, Antitumor,
pubmed-meshheading:10969982-Female,
pubmed-meshheading:10969982-Humans,
pubmed-meshheading:10969982-Molecular Structure,
pubmed-meshheading:10969982-Ovarian Neoplasms,
pubmed-meshheading:10969982-Pyrroles,
pubmed-meshheading:10969982-Tumor Cells, Cultured
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|
pubmed:year |
2000
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pubmed:articleTitle |
Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.
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pubmed:affiliation |
CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Science, University of Portsmouth, Hants, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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