Source:http://linkedlifedata.com/resource/pubmed/id/10969911
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2000-12-4
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pubmed:abstractText |
We review the etiology and age incidence of precocious puberty in 438 girls examined between 1988-1998; 428 (97.7%) had central precocious puberty (CPP), the remaining 10 (2.3%) gonadotropin-independent precocious puberty (GIPP) of ovarian origin. The majority of CPP girls (59.6%) were aged between 7-7.9 yr, 22.4% were 6 year olds, and only 18% were under 6 years old. Cranial CT and/or MRI performed in 304/428 girls, showed neurogenic abnormalities in 56/304 (18.4%) CPP girls; 30 (9.9%) were due to previously diagnosed intracranial abnormalities and the remaining 26 (8.5%) were detected at the diagnosis of CPP. The frequency of neurogenic CPP tended to be higher in girls under 4 years of age while the frequency of idiopathic CPP tended to be higher in girls aged between 7-7.9 years, but no statistically significant differences were found. Interestingly, some CNS anomalies either of tumoral or congenital origin were detected at presentation in 7% of the girls aged over 7 years. Other related or coincidental clinical anomalies, mainly due to genetic diseases, were observed in 22/304 (7.2%) patients. History of precocious maternal menarche was found in 12/304 (4%) girls. In conclusion, idiopathic CPP was observed in 74% of the girls in this study. Neurogenic anomalies or other coincidental or related clinical findings were observed in the remaining 26%. The increased frequency of idiopathic CPP in girls aged over 7 years may suggest an early, but otherwise normal onset of puberty in many of these girls as a consequence of the trend towards earlier maturation. Nonetheless, the finding of CNS anomalies also in the older patients, raises the question of whether these patients should undergo a complete diagnostic work-up.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0334-018X
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pubmed:author |
pubmed-author:AntoniazziFF,
pubmed-author:ArrigoTT,
pubmed-author:BeduschiLL,
pubmed-author:BindiGG,
pubmed-author:BorrelliPP,
pubmed-author:CisterninoMM,
pubmed-author:De SanctisVV,
pubmed-author:FarelloGG,
pubmed-author:GalluzziFF,
pubmed-author:GargantiniLL,
pubmed-author:Lo PrestiDD,
pubmed-author:PasquinoA MAM,
pubmed-author:SpositoMM,
pubmed-author:TatòLL,
pubmed-author:TinelliCC
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pubmed:issnType |
Print
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pubmed:volume |
13 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
695-701
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10969911-Abnormalities, Multiple,
pubmed-meshheading:10969911-Age Distribution,
pubmed-meshheading:10969911-Brain Diseases,
pubmed-meshheading:10969911-Child,
pubmed-meshheading:10969911-Child, Preschool,
pubmed-meshheading:10969911-Female,
pubmed-meshheading:10969911-Genetic Diseases, Inborn,
pubmed-meshheading:10969911-Humans,
pubmed-meshheading:10969911-Incidence,
pubmed-meshheading:10969911-Italy,
pubmed-meshheading:10969911-Magnetic Resonance Imaging,
pubmed-meshheading:10969911-Medical Records,
pubmed-meshheading:10969911-Puberty, Precocious,
pubmed-meshheading:10969911-Tomography, X-Ray Computed
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pubmed:year |
2000
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pubmed:articleTitle |
Etiology and age incidence of precocious puberty in girls: a multicentric study.
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pubmed:affiliation |
Department of Pediatrics, IRCCS Policlinico S. Matteo, University of Pavia, Italy. m.cisternino@smatteo.pv.it
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pubmed:publicationType |
Journal Article,
Multicenter Study
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