Linked Life Data

10968944

Source:http://linkedlifedata.com/resource/pubmed/id/10968944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2000-10-6
pubmed:abstractText
Triterpene glycosides from sea cucumbers (Holothurioidea, Echinodermata) are used as a model for studying the biochemical evolution for correlation between the glycoside membranolytic activity and biological functions. Concepts of evolutionary morphology are applied at the molecular level. The concept of Van-der-Klaauve's- Dullemeijer's system-theoretical (holistic) approach is used for the model of structural-functional relationships of the glycosides. Network diagrams of structural-functional relationships have been prepared for many glycosides. The diagrams correlate well with experimental data and show a very complex and flexible action of the natural selection on the structural fragments of the glycosides. The diagrams also show overlapping in the functional components that provide stability to the general structural plan of glycosides during evolution. The method may be applied to other biomolecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-5193
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Academic Press.
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
206
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-68
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
System-theoretical (Holistic) approach to the modelling of structural-functional relationships of biomolecules and their evolution: an example of triterpene glycosides from sea cucumbers (Echinodermata, holothurioidea).
pubmed:affiliation
Far Eastern Division of the Russian Academy of Sciences, Pacific Institute of Bioorganic Chemistry, Vladivostok, 690022, Russia. kalininv@hotmail.com
pubmed:publicationType
Journal Article