10967352

Source:http://linkedlifedata.com/resource/pubmed/id/10967352

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0009170, umls-concept:C0011892, umls-concept:C0034693, umls-concept:C0035020, umls-concept:C0282443, umls-concept:C1552617
pubmed:issue	1
pubmed:dateCreated	2000-9-28
pubmed:abstractText	Studies in humans suggest that exposure to stress increases the probability of relapse to drug use, but until recently there has been no animal model to study the mechanisms that mediate this effect. We have developed a reinstatement procedure that allows us to study the effect of stress on relapse to drug seeking in rats. Using this procedure, we have shown that exposure to intermittent footshock stress reliably reinstates heroin and cocaine seeking after prolonged drug-free periods. In the present paper, we summarize results from several studies on stress-induced reinstatement of heroin and cocaine seeking in rats. We first assess the degree to which the phenomenon of stress-induced relapse generalizes to other stressors, to behaviors controlled by other drugs of abuse, and to behaviors controlled by non-drug reinforcers. We then review evidence from studies concerned with the neurotransmitters, the brain sites, and the neural systems involved in stress-induced reinstatement of drug seeking. Finally, we consider the mechanisms that might underlie stress-induced relapse to drug seeking and the possible implications of the findings for the treatment of relapse to drug use in humans.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8908638
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:author	pubmed-author:ErbSS, pubmed-author:ShahamYY, pubmed-author:StewartJJ
pubmed:volume	33
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	13-33
pubmed:dateRevised	2008-11-21
pubmed:meshHeading	pubmed-meshheading:10967352-Animals, pubmed-meshheading:10967352-Cocaine-Related Disorders, pubmed-meshheading:10967352-Heroin Dependence, pubmed-meshheading:10967352-Humans, pubmed-meshheading:10967352-Rats, pubmed-meshheading:10967352-Recurrence, pubmed-meshheading:10967352-Stress, Physiological
pubmed:year	2000
pubmed:articleTitle	Stress-induced relapse to heroin and cocaine seeking in rats: a review.
pubmed:affiliation	Behavioral Neuroscience Branch, IRP/NIDA/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. yshaham@intra.nida.nih.gov
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't