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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-10-5
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pubmed:abstractText |
During the last decade, experimental and clinical evidence has accumulated that antithrombin (AT) exerts anti-inflammatory effects when given in high doses. Meanwhile, AT substitution has been shown to significantly increase prostacyclin release. However, the link between endothelial AT binding and anti-inflammatory AT effects remains to be established in vivo, although heparin has been shown to counteract anti-inflammatory AT effects. We hypothesized that the administration of heparin in endotoxin-challenged rats would decrease endothelial AT binding and systemic prostacyclin concentrations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0090-3493
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2881-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10966265-Animals,
pubmed-meshheading:10966265-Anticoagulants,
pubmed-meshheading:10966265-Antithrombins,
pubmed-meshheading:10966265-Heparin,
pubmed-meshheading:10966265-Hirudin Therapy,
pubmed-meshheading:10966265-Lipopolysaccharides,
pubmed-meshheading:10966265-Male,
pubmed-meshheading:10966265-Prospective Studies,
pubmed-meshheading:10966265-Random Allocation,
pubmed-meshheading:10966265-Rats,
pubmed-meshheading:10966265-Rats, Wistar,
pubmed-meshheading:10966265-Thrombin
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pubmed:year |
2000
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pubmed:articleTitle |
Influence of heparin and hirudin on endothelial binding of antithrombin in experimental thrombinemia.
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pubmed:affiliation |
Klinik für Anästhesiologie und operative Intensivmedizin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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