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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-11-22
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pubmed:abstractText |
Lipid response to dietary fat and cholesterol is, to a large extent, genetically controlled. Apolipoprotein B (apo B) plays a dominant role in cholesterol homeostasis. Several polymorphic sites within or adjacent to the gene locus for apo B have been detected. The X+ allele of the XbaI restriction fragment polymorphism of the apo B gene has been found to be associated with higher serum cholesterol and/or triglyceride levels. In order to study the influence of this mutation on the plasma lipid response in diets of varying fat content, 72 healthy male subjects were studied, 21 X- X- (X-) and 51 X+ (X+ X- or X+ X+).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2972
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
678-84
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10964159-Adult,
pubmed-meshheading:10964159-Alleles,
pubmed-meshheading:10964159-Apolipoprotein A-I,
pubmed-meshheading:10964159-Apolipoproteins B,
pubmed-meshheading:10964159-Body Mass Index,
pubmed-meshheading:10964159-Cholesterol,
pubmed-meshheading:10964159-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:10964159-Diet Records,
pubmed-meshheading:10964159-Dietary Fats,
pubmed-meshheading:10964159-Fatty Acids,
pubmed-meshheading:10964159-Genotype,
pubmed-meshheading:10964159-Humans,
pubmed-meshheading:10964159-Lipids,
pubmed-meshheading:10964159-Male,
pubmed-meshheading:10964159-Polymorphism, Restriction Fragment Length
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pubmed:year |
2000
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pubmed:articleTitle |
The effect of apolipoprotein B xbaI polymorphism on plasma lipid response to dietary fat.
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pubmed:affiliation |
Servicio de Medicina Interna, Hospital Alto Guadalquivir, Andujar, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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