| pubmed-article:10963811 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10963811 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
| pubmed-article:10963811 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:10963811 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:10963811 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10963811 | pubmed:dateCreated | 2000-9-15 | lld:pubmed |
| pubmed-article:10963811 | pubmed:abstractText | We studied the Th2/Th1 balance by short-term stimulation of peripheral blood mononuclear cells (PBMC) isolated during the pollen season from seven allergic patients treated with conventional birch-pollen immunotherapy (IT) for 18 months, eight matched allergic control patients and 10 non-atopic individuals. The PBMC were cultured for 7 days with birch-pollen extract (BPE) or tetanus toxoid (TT), and then restimulated with PHA and PMA to induce high IL-5, IL-10 and IFN-gamma production. The serum levels of birch-pollen-specific IgG and IgG4 were significantly elevated after IT treatment. The proliferative response to BPE was significantly enhanced in the allergic control group, but not in the IT-treated group, compared to the non-atopic group (P<0.05). Birch-pollen-specific IL-5 production was significantly enhanced in both the IT-treated group and the allergic control group (P<0.01-0. 05). Furthermore, both the IT-treated group and the allergic control group had a cytokine profile to BPE significantly more Th2 polarized (high IL-5/IFN-gamma ratio) than to TT (P<0.05 and P<0.01, respectively). No differences in IL-10 production between the three study groups were observed. The Th2/Th1 balance in vitro correlated with the serum concentrations of birch-pollen-specific IgE (r=0.60, P<0.05), and in the IT-treated group, also with the IgG and IgG4 levels (r=0.79, P<0.05 and r=0.86, P<0.05, respectively). We conclude that conventional birch-pollen IT does not lead to changes in the cytokine profile of the circulating pool of allergen-specific T cells during birch-pollen season. However, induction of peripheral T-cell tolerance and increased production of specific IgG and IgG4 might be part of the mechanisms of IT. | lld:pubmed |
| pubmed-article:10963811 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10963811 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10963811 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10963811 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10963811 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:10963811 | pubmed:author | pubmed-author:StålenheimGG | lld:pubmed |
| pubmed-article:10963811 | pubmed:author | pubmed-author:ElfmanLL | lld:pubmed |
| pubmed-article:10963811 | pubmed:author | pubmed-author:BjörnssonEE | lld:pubmed |
| pubmed-article:10963811 | pubmed:author | pubmed-author:MovérareRR | lld:pubmed |
| pubmed-article:10963811 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10963811 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:10963811 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:10963811 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10963811 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10963811 | pubmed:pagination | 51-6 | lld:pubmed |
| pubmed-article:10963811 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10963811 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10963811 | pubmed:articleTitle | Cytokine production by peripheral blood mononuclear cells following birch-pollen immunotherapy. | lld:pubmed |
| pubmed-article:10963811 | pubmed:affiliation | Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.robert.moveare@eu.pnu.com | lld:pubmed |
| pubmed-article:10963811 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10963811 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:10963811 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
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