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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2000-10-12
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pubmed:databankReference |
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pubmed:abstractText |
Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-10373513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-10373529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-10469846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-10602461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-2249773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-2537468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-7520526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-7690960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-8306960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-8743703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-8858144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-8898208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9056887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9091804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9132271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9244310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9252186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9275204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9346241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9346484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9346485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9360994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9390693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9430229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9520401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9520446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9657155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9765209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10962024-9788276
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TRAF3IP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10489-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10962024-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10962024-Amino Acid Sequence,
pubmed-meshheading:10962024-Carrier Proteins,
pubmed-meshheading:10962024-Cell Line,
pubmed-meshheading:10962024-DNA, Complementary,
pubmed-meshheading:10962024-Enzyme Activation,
pubmed-meshheading:10962024-Helix-Loop-Helix Motifs,
pubmed-meshheading:10962024-Humans,
pubmed-meshheading:10962024-Interleukin-1,
pubmed-meshheading:10962024-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10962024-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10962024-Molecular Sequence Data,
pubmed-meshheading:10962024-NF-kappa B,
pubmed-meshheading:10962024-Recombinant Proteins,
pubmed-meshheading:10962024-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10962024-Trans-Activators,
pubmed-meshheading:10962024-Tumor Necrosis Factor Receptor-Associated Peptides and...
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pubmed:year |
2000
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pubmed:articleTitle |
Act1, an NF-kappa B-activating protein.
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pubmed:affiliation |
Departments of Immunology and Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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