Linked Life Data

10961967

Source:http://linkedlifedata.com/resource/pubmed/id/10961967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2000-9-14
pubmed:abstractText
BACKGROUND: Several epidemiological studies have demonstrated the beneficial effect of red wine intake in reducing total and cardiovascular mortality. This effect has been attributed in part to its antioxidant properties. Because the monocytes/macrophages and the nuclear transcription factor kappaB (NF-kappaB) are implicated in the pathogenesis of atherosclerotic lesions, we examined the effect of red wine intake on the activation of NF-kappaB in peripheral blood mononuclear cells. METHODS AND RESUTLS: Sixteen healthy volunteers were studied 3 times each: after a moderate dose, a low dose, and no wine with a fat-enriched breakfast. Lipid profile and NF-kappaB activation (electrophoretic mobility shift assay) were examined in blood samples taken before and 3, 6, and 9 hours after wine intake. In addition, mononuclear cells were incubated with VLDL in the presence of some antioxidants (quercetin and alpha-tocopherol succinate) contained in red wine to study their effects on NF-kappaB activation. Subjects receiving a fat-enriched breakfast had increased NF-kappaB activation in peripheral blood mononuclear cells coinciding with the augmentation in total triglycerides and chylomicrons. Red wine intake prevented NF-kappaB activity even though it induced a certain increase in serum lipids, particularly VLDL, that did not increase after the fat ingestion alone. However, another form of alcohol intake (vodka) did not modify the NF-kappaB activation provided by postprandial lipemia. In cultured mononuclear cells, isolated human VLDL caused NF-kappaB activation in a time-dependent manner that did not occur in the presence of the red wine antioxidants quercetin and alpha-tocopherol. CONCLUSIONS: Our results provide a new potential mechanism to explain the beneficial effects of red wine intake in the reduction of cardiovascular mortality.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1524-4539
pubmed:author
pubmed:issnType
Electronic
pubmed:day
29
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1020-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10961967-Adult, pubmed-meshheading:10961967-Antioxidants, pubmed-meshheading:10961967-Arteriosclerosis, pubmed-meshheading:10961967-Cell Line, pubmed-meshheading:10961967-Dietary Fats, pubmed-meshheading:10961967-Dose-Response Relationship, Drug, pubmed-meshheading:10961967-Female, pubmed-meshheading:10961967-Humans, pubmed-meshheading:10961967-Lipid Metabolism, pubmed-meshheading:10961967-Lipids, pubmed-meshheading:10961967-Lipoproteins, VLDL, pubmed-meshheading:10961967-Male, pubmed-meshheading:10961967-Monocytes, pubmed-meshheading:10961967-NF-kappa B, pubmed-meshheading:10961967-Postprandial Period, pubmed-meshheading:10961967-Quercetin, pubmed-meshheading:10961967-Time Factors, pubmed-meshheading:10961967-Triglycerides, pubmed-meshheading:10961967-Vitamin E, pubmed-meshheading:10961967-Wine
pubmed:year
2000
pubmed:articleTitle
Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia.
pubmed:affiliation
Research Laboratory, Instituto de Investigación Médica, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't