Linked Life Data

10961881

Source:http://linkedlifedata.com/resource/pubmed/id/10961881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-10-18
pubmed:abstractText
Cytochrome P-450 2C9 is the principle enzyme that terminates the anticoagulant effect of warfarin. Genetic polymorphisms in CYP2C9 producing variants with altered catalytic properties have been identified. Patients (n = 561) with a target international normalized ratio (INR) of 2.5 who had been treated with warfarin for more than 2 months were anonymously genotyped for the wild-type CYP2C9*1 allele and the 2C9*2 and 2C9*3 variants. The mean maintenance dose of warfarin in patients who were wild-type for both alleles was 5.01 mg. The maintenance dose of warfarin was significantly related to genotype (Kruskall-Wallis, chi(2) = 17.985, P =.001) with mean maintenance doses in patients with variant alleles between 61% and 86% of that in wild-type patients. The odds ratio for the 2C9*2 allele in patients with a maintenance dose of 1. 5 mg or less was 5.42 (95% CI 1.68-17.4). The odds ratio for one or more variant alleles in patients developing an INR of 8.0 or greater was 1.52 (95% CI 0.64-3.58). The SD of the mean INR, percentage of high INRs, and person-time spent in range were determined as parameters of stability. There was no difference between patients grouped according to genotype for any parameter of stability. This study confirmed an association between CYP2C9 genotype and warfarin sensitivity. However, the possession of a variant allele does not increase the likelihood of severe over-anticoagulation or stability of anticoagulation during long-term therapy. (Blood. 2000;96:1816-1819)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1816-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10961881-Alleles, pubmed-meshheading:10961881-Anticoagulants, pubmed-meshheading:10961881-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:10961881-Blood Coagulation, pubmed-meshheading:10961881-Cohort Studies, pubmed-meshheading:10961881-Cytochrome P-450 Enzyme System, pubmed-meshheading:10961881-Dose-Response Relationship, Drug, pubmed-meshheading:10961881-Genotype, pubmed-meshheading:10961881-Humans, pubmed-meshheading:10961881-International Normalized Ratio, pubmed-meshheading:10961881-Polymorphism, Genetic, pubmed-meshheading:10961881-Risk Factors, pubmed-meshheading:10961881-Statistics as Topic, pubmed-meshheading:10961881-Steroid 16-alpha-Hydroxylase, pubmed-meshheading:10961881-Steroid Hydroxylases, pubmed-meshheading:10961881-Time Factors, pubmed-meshheading:10961881-Warfarin
pubmed:year
2000
pubmed:articleTitle
Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.
pubmed:affiliation
Department of Haematology, Addenbrooke's NHS Trust, Cambridge, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't