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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13 Spec No
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pubmed:dateCreated |
2000-11-7
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pubmed:abstractText |
E-cadherin and the associated catenin complex have been recognised as performing a key role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to tumour metastasis. The ability of both extra- and intracellular factors to regulate E-cadherin-mediated cell adhesion in physiological processes has provided insight into both the interactions of the E-cadherin-catenin complex, and possible mechanisms utilised by tumours in the process of metastasis. The interaction of the E-cadherin-catenin complex with various regulating factors, their effect on cell signalling pathways, and the relationship with the metastatic potential of tumours are reviewed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0959-8049
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1607-20
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10959047-Cadherins,
pubmed-meshheading:10959047-Cell Adhesion,
pubmed-meshheading:10959047-Cell Hypoxia,
pubmed-meshheading:10959047-Cytoskeletal Proteins,
pubmed-meshheading:10959047-Genes, APC,
pubmed-meshheading:10959047-Humans,
pubmed-meshheading:10959047-Neoplasm Metastasis,
pubmed-meshheading:10959047-Trans-Activators,
pubmed-meshheading:10959047-alpha Catenin,
pubmed-meshheading:10959047-beta Catenin
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pubmed:year |
2000
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|
pubmed:articleTitle |
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
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pubmed:affiliation |
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa. nesinsa@global.co.za
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pubmed:publicationType |
Journal Article,
Review
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