Linked Life Data

10955808

Source:http://linkedlifedata.com/resource/pubmed/id/10955808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-11-27
pubmed:abstractText
PTEN, a candidate tumor suppressor gene located at chromosome 10q23.3, has been shown to be mutated in approximately 40% of endometrial cancers. Such mutations have also been identified in endometrial hyperplasia, indicating that inactivation of the PTEN tumor suppressor gene is an early event in the genesis of some endometrial cancers. In this study, we have extended the analysis of PTEN in gynecological cancer to include adenocarcinoma of the cervix and vulvar carcinomas. Microdissected tissue (including normal tissues), preneoplastic, and neoplastic lesions were analyzed from 9 patients with cervical cancer and 10 patients with vulvar cancer. Only 1 cervical adenocarcinoma displayed a PTEN mutation. In contrast, five of eight vulvar carcinomas studied harbored PTEN mutations. Alterations were identified in carcinoma in situ as well as squamous cell carcinoma of the vulva. In two patients, PTEN mutations were identified in mucosal regions with mild or focal dysplasia. These results suggest that PTEN is frequently altered in vulvar carcinomas and can be found associated with early dysplastic changes in vulvar mucosa.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3228-35
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10955808-Adenocarcinoma, pubmed-meshheading:10955808-Carcinoma, Squamous Cell, pubmed-meshheading:10955808-Carcinoma in Situ, pubmed-meshheading:10955808-Endometrial Neoplasms, pubmed-meshheading:10955808-Female, pubmed-meshheading:10955808-Humans, pubmed-meshheading:10955808-Hyperplasia, pubmed-meshheading:10955808-Mutation, pubmed-meshheading:10955808-PTEN Phosphohydrolase, pubmed-meshheading:10955808-Phosphoric Monoester Hydrolases, pubmed-meshheading:10955808-Polymerase Chain Reaction, pubmed-meshheading:10955808-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:10955808-Sensitivity and Specificity, pubmed-meshheading:10955808-Tumor Suppressor Proteins, pubmed-meshheading:10955808-Uterine Cervical Neoplasms, pubmed-meshheading:10955808-Vulva, pubmed-meshheading:10955808-Vulvar Neoplasms
pubmed:year
2000
pubmed:articleTitle
Somatic mutation of PTEN in vulvar cancer.
pubmed:affiliation
Department of Research, Robert E. Wise M. D. Research and Education Institute, Burlington, Massachusetts 01805, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't