Source:http://linkedlifedata.com/resource/pubmed/id/10954885
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2000-12-11
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pubmed:abstractText |
We evaluated factors associated with incident self-reported AIDS diagnoses among HIV-infected women in the Women's Interagency HIV Study (WIHS). Baseline information included age, race/ethnicity, HIV risk category, site of enrollment, years of education, cigarette smoking, CD4 cell count, and HIV viral load. Baseline and follow-up data on self-reported AIDS were analyzed using chi-square, Kaplan-Meier, and Cox proportional hazard models. Among the 1397 HIV-infected women who reported being free of clinical AIDS at baseline, 335 women (24%) reported an incident AIDS diagnosis during follow-up. In stratified Kaplan-Meier analyses, the development of self-reported AIDS was significantly associated with baseline CD4 cell count and viral load (p<0.01). In multivariate Cox proportional hazard analyses, women were statistically more likely to report AIDS if they had CD4 cell counts below 195 cells/mm3 (p<0.01), HIV RNA >4000 copies/ml (p<0.01), were current smokers (p<0.01), and had "no identifiable risk" for acquisition of HIV (p = 0.03). Self-reports of a clinical AIDS diagnosis may not always be accurate, but laboratory markers of HIV disease indicate that those women who self-report such diagnoses have greater immunodeficiency and a higher viral load when compared with those who report no AIDS-defining diagnoses.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0889-2229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1105-11
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10954885-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10954885-Adolescent,
pubmed-meshheading:10954885-Adult,
pubmed-meshheading:10954885-Age Factors,
pubmed-meshheading:10954885-Continental Population Groups,
pubmed-meshheading:10954885-Educational Status,
pubmed-meshheading:10954885-Ethnic Groups,
pubmed-meshheading:10954885-Female,
pubmed-meshheading:10954885-HIV Infections,
pubmed-meshheading:10954885-Humans,
pubmed-meshheading:10954885-Incidence,
pubmed-meshheading:10954885-Middle Aged,
pubmed-meshheading:10954885-RNA, Viral,
pubmed-meshheading:10954885-Risk Factors,
pubmed-meshheading:10954885-Smoking,
pubmed-meshheading:10954885-United States,
pubmed-meshheading:10954885-Viral Load,
pubmed-meshheading:10954885-Women's Health
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pubmed:year |
2000
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pubmed:articleTitle |
Factors associated with incident self-reported AIDS among women enrolled in the women's interagency HIV study (WIHS). WIHS Collaboratorive Study Group.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco 94122, USA. nancyh@itsa.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Multicenter Study
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