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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2000-10-5
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pubmed:databankReference |
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pubmed:abstractText |
IL-10-related T cell-derived inducible factor (IL-TIF or IL-21) is a new cytokine structurally related to IL-10 and originally identified in the mouse as a gene induced by IL-9 in T cells and mast cells. Here, we report the cloning of the human IL-TIF cDNA, which shares 79% amino acid identity with mouse IL-TIF and 25% identity with human IL-10. Recombinant human IL-TIF was found to activate signal transducer and activator of transcription factors-1 and -3 in several hepatoma cell lines. IL-TIF stimulation of HepG2 human hepatoma cells up-regulated the production of acute phase reactants such as serum amyloid A, alpha1-antichymotrypsin, and haptoglobin. Although IL-10 and IL-TIF have distinct activities, antibodies directed against the beta chain of the IL-10 receptor blocked the induction of acute phase reactants by IL-TIF, indicating that this chain is a common component of the IL-10 and IL-TIF receptors. Similar acute phase reactant induction was observed in mouse liver upon IL-TIF injection, and IL-TIF expression was found to be rapidly increased after lipopolysaccharide (LPS) injection, suggesting that this cytokine contributes to the inflammatory response in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-10504381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-10586112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-10657629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-10729163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-1689567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-1725967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-2145361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-2454192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-2521242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-6208485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-6546723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-7512342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-8164674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-8756628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-8841195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-8921368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-9312047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-9463407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-9634527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-9700192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10954742-9716487
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10144-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10954742-Acute-Phase Proteins,
pubmed-meshheading:10954742-Amino Acid Sequence,
pubmed-meshheading:10954742-Animals,
pubmed-meshheading:10954742-Carcinoma, Hepatocellular,
pubmed-meshheading:10954742-Cell Line,
pubmed-meshheading:10954742-Cells, Cultured,
pubmed-meshheading:10954742-Cloning, Molecular,
pubmed-meshheading:10954742-Cytokines,
pubmed-meshheading:10954742-DNA, Complementary,
pubmed-meshheading:10954742-Escherichia coli,
pubmed-meshheading:10954742-Female,
pubmed-meshheading:10954742-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10954742-Humans,
pubmed-meshheading:10954742-Interleukin-10,
pubmed-meshheading:10954742-Liver Neoplasms,
pubmed-meshheading:10954742-Mice,
pubmed-meshheading:10954742-Mice, Inbred C3H,
pubmed-meshheading:10954742-Molecular Sequence Data,
pubmed-meshheading:10954742-Recombinant Proteins,
pubmed-meshheading:10954742-Sequence Alignment,
pubmed-meshheading:10954742-Sequence Homology, Amino Acid,
pubmed-meshheading:10954742-Signal Transduction,
pubmed-meshheading:10954742-T-Lymphocytes,
pubmed-meshheading:10954742-Trans-Activators,
pubmed-meshheading:10954742-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Brussels Branch and the Experimental Medicine Unit, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, Avenue Hippocrate 74, B1200-Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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