| pubmed-article:10954610 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C1704661 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C1539816 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0919550 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10954610 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10954610 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:10954610 | pubmed:dateCreated | 2000-10-3 | lld:pubmed |
| pubmed-article:10954610 | pubmed:abstractText | Exposure of Schizosaccharomyces pombe cells to UV light results in increased uvi15(+) gene expression at both the mRNA and protein levels, leading to elevated cell survival. This UV-induced expression of the uvi15(+) gene was reduced in Deltasty1 and Deltawis1 cells lacking the stress-activated protein kinase pathway, but not in DNA damage checkpoint mutants. To further understand the cellular mechanisms responsible for this UV-induced expression, the transcription rate and mRNA half-life were investigated. Transcription run-on assays revealed that the rate of uvi15(+) transcription was increased 1.8-fold regardless of Sty1 when cells were UV irradiated. The half-life of uvi15(+) mRNA was also increased 1.5-fold after UV irradiation, but it was decreased in the Deltasty1 background for both basal and UV-induced mRNAs, indicating that the stress-activated MAPK cascade can mediate UV-induced gene expression by increasing mRNA half-life. Deletion analyses identified a 54 nt element downstream of the distal poly(A) site, which was involved in the increased half-life of uvi15(+) mRNA. These results suggest that both Sty1 and the 3'-regulatory element regulate UV-induced expression of the uvi15(+) gene at the post-transcriptional level. | lld:pubmed |
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| pubmed-article:10954610 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10954610 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10954610 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10954610 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10954610 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10954610 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10954610 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:ParkJJ | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:LeaSS | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:KimMM | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:ParkS DSD | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:CHES PSP | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:SeongR HRH | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:ChoeS YSY | lld:pubmed |
| pubmed-article:10954610 | pubmed:author | pubmed-author:JangY KYK | lld:pubmed |
| pubmed-article:10954610 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:10954610 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10954610 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:10954610 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10954610 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10954610 | pubmed:pagination | 3392-402 | lld:pubmed |
| pubmed-article:10954610 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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