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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3 Pt 1
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pubmed:dateCreated |
2000-9-14
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pubmed:abstractText |
Numerous advances have been made in gene therapy approaches for the treatment of solid tumors, including prostate cancer. While treatment of the primary tumor has been well investigated, little information is available regarding gene therapy techniques which might impact on the progression to metastatic disease. We investigate the ability of p53 adenovirus to suppress not only primary tumor growth, but also the progression to metastatic disease. Mutation of the p53 tumor suppressor gene has been associated with the progression of prostate cancer. In this study, we utilized a metastatic model for human prostate cancer to determine if introduction of the wild-type p53 gene using an adenoviral vector (rAd-p53) impacted on primary tumor growth as well as the progression to metastatic disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
814-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10953161-Adenoviridae,
pubmed-meshheading:10953161-Animals,
pubmed-meshheading:10953161-Antigens, Nuclear,
pubmed-meshheading:10953161-Apoptosis,
pubmed-meshheading:10953161-Cell Division,
pubmed-meshheading:10953161-Cell Nucleus,
pubmed-meshheading:10953161-Chi-Square Distribution,
pubmed-meshheading:10953161-DNA-Binding Proteins,
pubmed-meshheading:10953161-Disease Models, Animal,
pubmed-meshheading:10953161-Disease Progression,
pubmed-meshheading:10953161-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10953161-Gene Therapy,
pubmed-meshheading:10953161-Genes, p53,
pubmed-meshheading:10953161-Genes, ras,
pubmed-meshheading:10953161-Genetic Vectors,
pubmed-meshheading:10953161-Humans,
pubmed-meshheading:10953161-Male,
pubmed-meshheading:10953161-Mice,
pubmed-meshheading:10953161-Mice, Inbred BALB C,
pubmed-meshheading:10953161-Mice, Nude,
pubmed-meshheading:10953161-Mutation,
pubmed-meshheading:10953161-Neoplasm Metastasis,
pubmed-meshheading:10953161-Nuclear Proteins,
pubmed-meshheading:10953161-Prostatic Neoplasms,
pubmed-meshheading:10953161-Proto-Oncogene Proteins p21(ras),
pubmed-meshheading:10953161-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Suppression of primary tumor growth and the progression to metastasis with p53 adenovirus in human prostate cancer.
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pubmed:affiliation |
Departments of Urology, Pathology and Biochemistry/Molecular Biology, Louisiana State University Medical Center, Shreveport 71130-3932, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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