Source:http://linkedlifedata.com/resource/pubmed/id/10952944
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2000-9-6
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| pubmed:abstractText |
Fibroblast growth factor-10 (FGF-10) is a stromal-derived paracrine growth factor considered to be important during embryogenesis; however, its expression by cells in the female reproductive tract has not been investigated. Therefore, an ovine FGF-10 cDNA was cloned from an ovine endometrial cDNA library to investigate expression and potential paracrine characteristics of FGF-10 in the ovine uterus. The ovine FGF-10 cDNA encodes a protein of 213 amino acids and possesses an unusually long 5' untranslated region (UTR). In situ hybridization demonstrated that ovine FGF-10 mRNA was expressed by endometrial stromal cells and by mesenchymal cells of the chorioallantoic placenta. The mRNA for FGF-7, a homologue of FGF-10, was localized in the tunica muscularis of blood vessels in endometrium and myometrium. In contrast, FGF receptor 2IIIb, the high-affinity receptor for both FGF-10 and FGF-7, was expressed exclusively in luminal epithelium, glandular epithelium, and placental trophectoderm. The in vivo spatial expression pattern suggests that FGF-10 is a novel endometrial stromal cell-derived mediator of uterine epithelial and conceptus trophectodermal functions. The nonoverlapping spatial patterns of expression for FGF-10 and FGF-7 in ovine uterus and conceptus suggest independent roles in uterine function and conceptus development.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/FGF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 10,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
|
| pubmed:issn |
0006-3363
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
959-66
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10952944-Amino Acid Sequence,
pubmed-meshheading:10952944-Animals,
pubmed-meshheading:10952944-DNA, Complementary,
pubmed-meshheading:10952944-Endometrium,
pubmed-meshheading:10952944-Epithelium,
pubmed-meshheading:10952944-Female,
pubmed-meshheading:10952944-Fibroblast Growth Factor 10,
pubmed-meshheading:10952944-Fibroblast Growth Factors,
pubmed-meshheading:10952944-Gene Expression,
pubmed-meshheading:10952944-Humans,
pubmed-meshheading:10952944-In Situ Hybridization,
pubmed-meshheading:10952944-Molecular Sequence Data,
pubmed-meshheading:10952944-RNA, Messenger,
pubmed-meshheading:10952944-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10952944-Sequence Alignment,
pubmed-meshheading:10952944-Sheep,
pubmed-meshheading:10952944-Stromal Cells,
pubmed-meshheading:10952944-Uterus
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| pubmed:year |
2000
|
| pubmed:articleTitle |
Fibroblast growth factor-10: a stromal mediator of epithelial function in the ovine uterus.
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| pubmed:affiliation |
Center for Animal Biotechnology and Genomics, and Department of Animal Science, Texas A&M University,College Station, Texas 77843-2471, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|