Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-1-26
pubmed:abstractText
Tumor necrosis factor alpha (TNF-alpha) is the key mediator of superantigen-induced T cell lethal shock. Here, we show that nuclear factor of activated T cells transcription factor, NFATp, controls susceptibility to superantigen-induced lethal shock in mice through its activation of TNF-alpha gene transcription. In NFATp-deficient mice, T cell stimulation leads to delayed induction and attenuation of TNF-alpha mRNA levels, decreased TNF-alpha serum levels, and resistance to superantigen-induced lethal shock. By contrast, after lipopolysaccharide (LPS) challenge, serum levels of TNF-alpha and susceptibility to shock are unaffected. These results demonstrate that NFATp is an essential activator of immediate early TNF-alpha gene expression in T cells and they present in vivo evidence of the inducer- and cell type-specific regulation of TNF-alpha gene expression. Furthermore, they suggest NFATp as a potential selective target in the treatment of superantigen-induced lethal shock.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-10089876, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-10377394, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-10688670, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-10913190, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-1730929, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-2185544, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-2521300, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-2522086, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-3259256, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-3317066, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-3819645, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-3949385, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-6972418, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-7749981, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-7982959, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8046352, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8202141, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8235597, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8376940, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8552071, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8612134, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8637514, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-8816436, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-9143705, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-9359687, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-9430230, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-9462517, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952728-9846484
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
581-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10952728-Animals, pubmed-meshheading:10952728-DNA-Binding Proteins, pubmed-meshheading:10952728-Enterotoxins, pubmed-meshheading:10952728-Female, pubmed-meshheading:10952728-Gene Expression Regulation, pubmed-meshheading:10952728-Humans, pubmed-meshheading:10952728-Lipopolysaccharides, pubmed-meshheading:10952728-Liver, pubmed-meshheading:10952728-Male, pubmed-meshheading:10952728-Mice, pubmed-meshheading:10952728-Mice, Inbred Strains, pubmed-meshheading:10952728-NFATC Transcription Factors, pubmed-meshheading:10952728-Nuclear Proteins, pubmed-meshheading:10952728-Promoter Regions, Genetic, pubmed-meshheading:10952728-RNA, Messenger, pubmed-meshheading:10952728-Shock, Septic, pubmed-meshheading:10952728-Spleen, pubmed-meshheading:10952728-Superantigens, pubmed-meshheading:10952728-T-Lymphocytes, pubmed-meshheading:10952728-Transcription Factors, pubmed-meshheading:10952728-Tumor Necrosis Factor-alpha
pubmed:year
2000
pubmed:articleTitle
Nuclear factor of activated T cells transcription factor NFATp controls superantigen-induced lethal shock.
pubmed:affiliation
Center for Blood Research and Harvard Medical School and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't