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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-11-7
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pubmed:abstractText |
Among the Oji-Cree of northern Ontario, women have both a higher prevalence and an earlier onset of type 2 diabetes compared to men. We studied the relationship between HNF1A S319 and both the presence of and the age-of-onset of type 2 diabetes in women and men separately. We found that: 1) in women, there was a significant difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype; and 2) in men, there was no difference in the mean age-of-onset of type 2 diabetes according to HNF1A genotype. The findings indicate that HNF1A S319 is associated with increased susceptibility to type 2 diabetes in both men and women, but with earlier age-of-onset in women only. One factor that might account for the gender difference in the onset of HNF1A S319-associated type 2 diabetes is the greater prevalence and severity, and earlier onset of, obesity among female Oji-Cree.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0307-0565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1062-4
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pubmed:dateRevised |
2008-9-11
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pubmed:meshHeading |
pubmed-meshheading:10951547-Adolescent,
pubmed-meshheading:10951547-Adult,
pubmed-meshheading:10951547-Age of Onset,
pubmed-meshheading:10951547-Aged,
pubmed-meshheading:10951547-Aged, 80 and over,
pubmed-meshheading:10951547-Analysis of Variance,
pubmed-meshheading:10951547-Asian Continental Ancestry Group,
pubmed-meshheading:10951547-Child,
pubmed-meshheading:10951547-Cohort Studies,
pubmed-meshheading:10951547-DNA-Binding Proteins,
pubmed-meshheading:10951547-Diabetes Mellitus, Type 2,
pubmed-meshheading:10951547-Female,
pubmed-meshheading:10951547-Genotype,
pubmed-meshheading:10951547-Hepatocyte Nuclear Factor 1,
pubmed-meshheading:10951547-Hepatocyte Nuclear Factor 1-alpha,
pubmed-meshheading:10951547-Hepatocyte Nuclear Factor 1-beta,
pubmed-meshheading:10951547-Humans,
pubmed-meshheading:10951547-Indians, North American,
pubmed-meshheading:10951547-Male,
pubmed-meshheading:10951547-Middle Aged,
pubmed-meshheading:10951547-Nuclear Proteins,
pubmed-meshheading:10951547-Obesity,
pubmed-meshheading:10951547-Ontario,
pubmed-meshheading:10951547-Prevalence,
pubmed-meshheading:10951547-Sex Factors,
pubmed-meshheading:10951547-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Gender, obesity, hepatic nuclear factor-1alpha G319S and the age-of-onset of type 2 diabetes in Canadian Oji-Cree.
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pubmed:affiliation |
John P Robarts Research Institute, London, Ontario, Canada. robert.hegele@rri.on.ca
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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