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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2000-11-21
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pubmed:abstractText |
Golgi-enriched membranes were phosphorylated in order to understand the mechanism for protein kinase C (PKC) regulation of exocytic vesicle formation at the trans-Golgi network. Two of the main PKC substrates were identified as MARCKS and Mac-MARCKS by two-dimensional electrophoresis (2-DE) and mass spectrometric sequencing. Annexin IV and profilin I, two other Golgi-associated proteins--although known as in vitro PKC substrates--were not phosphorylated in the Golgi-bound state.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A4,
http://linkedlifedata.com/resource/pubmed/chemical/Contractile Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/MARCKSL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PFN1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Profilins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/R-SNARE Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/VAMP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/myristoylated alanine-rich C...
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0173-0835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2684-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10949146-Annexin A4,
pubmed-meshheading:10949146-Blotting, Western,
pubmed-meshheading:10949146-Carcinoma, Hepatocellular,
pubmed-meshheading:10949146-Contractile Proteins,
pubmed-meshheading:10949146-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:10949146-Golgi Apparatus,
pubmed-meshheading:10949146-Humans,
pubmed-meshheading:10949146-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10949146-Isoenzymes,
pubmed-meshheading:10949146-Liver Neoplasms,
pubmed-meshheading:10949146-Membrane Proteins,
pubmed-meshheading:10949146-Microfilament Proteins,
pubmed-meshheading:10949146-Neoplasm Proteins,
pubmed-meshheading:10949146-Phosphorylation,
pubmed-meshheading:10949146-Profilins,
pubmed-meshheading:10949146-Protein Kinase C,
pubmed-meshheading:10949146-Protein Kinase C-alpha,
pubmed-meshheading:10949146-Protein Processing, Post-Translational,
pubmed-meshheading:10949146-Proteins,
pubmed-meshheading:10949146-R-SNARE Proteins,
pubmed-meshheading:10949146-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:10949146-Substrate Specificity,
pubmed-meshheading:10949146-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Protein kinase C alpha-dependent phosphorylation of Golgi proteins.
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pubmed:affiliation |
Cell Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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