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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-31
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pubmed:abstractText |
In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-108
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10949031-14-3-3 Proteins,
pubmed-meshheading:10949031-Amino Acid Sequence,
pubmed-meshheading:10949031-Animals,
pubmed-meshheading:10949031-Binding Sites,
pubmed-meshheading:10949031-Cell Division,
pubmed-meshheading:10949031-Cell Line,
pubmed-meshheading:10949031-Cell Survival,
pubmed-meshheading:10949031-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10949031-Hematopoietic System,
pubmed-meshheading:10949031-Interleukin-3,
pubmed-meshheading:10949031-Mice,
pubmed-meshheading:10949031-Mutagenesis, Site-Directed,
pubmed-meshheading:10949031-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:10949031-Phosphorylation,
pubmed-meshheading:10949031-Proteins,
pubmed-meshheading:10949031-Receptors, Interleukin-3,
pubmed-meshheading:10949031-Serine,
pubmed-meshheading:10949031-Signal Transduction,
pubmed-meshheading:10949031-Tyrosine 3-Monooxygenase
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pubmed:year |
2000
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pubmed:articleTitle |
Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.
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pubmed:affiliation |
Department of Human Immunology, The Hanson Centre for Cancer Research, IMVS, Adelaide, South Australia, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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