Linked Life Data

10948276

Source:http://linkedlifedata.com/resource/pubmed/id/10948276

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-10-19
pubmed:abstractText
A growing body of evidence suggests that polychlorinated naphthalenes (PCNs) may be fairly widespread environmental contaminants. This may be cause for concern because exposure to PCNs has been linked to dioxin-like biological responses in a wide variety of species. This study used three in vitro bioassays to characterize the dioxin-like potency of 18 individual PCN congeners and 1 PCN metabolite. The PLHC-1 fish hepatoma cell bioassay was relatively insensitive to PCNs. At the concentrations tested, only 1, 4 di-CN and 2,4-dichloro-1-napthol caused significant induction of ethoxyresorufin O-deethylase (EROD) activity in the PLHC-1 assay. In vitro EROD and luciferase assays using recombinant H4IIE rat hepatoma cells were more responsive to PCNs. Structure-activity relationships were observed both in terms of the degree of chlorination and the positions of chlorine substitutions. Hexa-chlorinated naphthalenes (CNs), exhibiting relative potencies (REPs) around 10(-3) (relative to TCDD), were the most potent congeners tested. Penta-CNs were also rather potent, yielding REPs between 10(-3) and 10(-7). Tetra-, tri-, di-, and mono-CNs were less active. REPs for the active congeners were similar to those for some PCBs. The relative potency estimates reported here contribute to an emerging body of information that will aid determination of the relative contribution of PCNs to the total dioxin-like activity associated with environmental samples.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0090-4341
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Relative potencies of individual polychlorinated naphthalenes to induce dioxin-like responses in fish and mammalian in vitro bioassays.
pubmed:affiliation
Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't