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rdf:type |
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lifeskim:mentions |
umls-concept:C0010749,
umls-concept:C0030685,
umls-concept:C0162638,
umls-concept:C0205263,
umls-concept:C0391871,
umls-concept:C0521451,
umls-concept:C0599894,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1335073,
umls-concept:C1367453,
umls-concept:C1425351,
umls-concept:C1963578
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pubmed:issue |
5482
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pubmed:dateCreated |
2000-8-31
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pubmed:abstractText |
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome c Group,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/NR4A1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/leptomycin B
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:CaoXX,
pubmed-author:ChenGG,
pubmed-author:DawsonM IMI,
pubmed-author:FontanaJ AJA,
pubmed-author:HUII,
pubmed-author:HobbsP DPD,
pubmed-author:KolluriS KSK,
pubmed-author:LiHH,
pubmed-author:LiaSS,
pubmed-author:LiuKK,
pubmed-author:LuJJ,
pubmed-author:ReedJ CJC,
pubmed-author:XieZZ,
pubmed-author:ZhangXX
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
289
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1159-64
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10947977-Apoptosis,
pubmed-meshheading:10947977-Cell Fractionation,
pubmed-meshheading:10947977-Cell Nucleus,
pubmed-meshheading:10947977-Cytochrome c Group,
pubmed-meshheading:10947977-DNA,
pubmed-meshheading:10947977-DNA-Binding Proteins,
pubmed-meshheading:10947977-Fatty Acids, Unsaturated,
pubmed-meshheading:10947977-Genes, Reporter,
pubmed-meshheading:10947977-Humans,
pubmed-meshheading:10947977-Intracellular Membranes,
pubmed-meshheading:10947977-Mitochondria,
pubmed-meshheading:10947977-Mutation,
pubmed-meshheading:10947977-Nuclear Receptor Subfamily 4, Group A, Member 1,
pubmed-meshheading:10947977-Protein Structure, Tertiary,
pubmed-meshheading:10947977-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10947977-Receptors, Steroid,
pubmed-meshheading:10947977-Recombinant Fusion Proteins,
pubmed-meshheading:10947977-Transcription Factors,
pubmed-meshheading:10947977-Transcriptional Activation,
pubmed-meshheading:10947977-Transfection,
pubmed-meshheading:10947977-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
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pubmed:affiliation |
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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