| pubmed-article:10947953 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0040005 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0040691 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1150423 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:10947953 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:10947953 | pubmed:dateCreated | 2001-1-2 | lld:pubmed |
| pubmed-article:10947953 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:abstractText | Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Recently some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 ('TAK1') have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. We also reported a TGF-beta response element in the human C-type natriuretic peptide (CNP) gene promoter. In this paper, we report on a novel factor which regulates the TGF-beta response promoter. This factor, named TSF1 (TGF-beta stimulated factor 1), possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. TSF1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. Interestingly, this factor had the structural features of a Ser/Thr kinase and actually exhibited protein kinase activity. TSF1 mRNA as well as its protein level were stimulated by TGF-beta treatment. Thus, TSF1 is an unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. | lld:pubmed |
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| pubmed-article:10947953 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10947953 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10947953 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10947953 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10947953 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10947953 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:TsujiTT | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:NagataKK | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:TakeuchiMM | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:OhtaSS | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:DeguchiMM | lld:pubmed |
| pubmed-article:10947953 | pubmed:author | pubmed-author:GaharaYY | lld:pubmed |
