10945456

Source:http://linkedlifedata.com/resource/pubmed/id/10945456

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020980, umls-concept:C0205460, umls-concept:C0450442, umls-concept:C0600364, umls-concept:C1527148
pubmed:issue	10-11
pubmed:dateCreated	2000-12-1
pubmed:abstractText	A critical need exists for a field deployable biosensor to detect environmental infectious agents in collected air samples rapidly, with sensitivity and specificity approaching that of standard laboratory procedures. The ideal sensor would analyze unknown samples in minutes, have programmable operation for unattended sample analysis, and be capable of multiple agent analysis for a number of agents. The goal of this project was to further the development of the bidiffractive grating biosensor (BDG) created through collaboration between Battelle Memorial Institute (BMI), Hoffman LaRoche (HLR), and the Naval Medical Research Command (NMRC). This manuscript details the development, optimization, and evaluation of this device as a potential field deployable biosensor. Well-characterized immunochemical reagents developed by the Biological Defense Research Department (BDRD) at NMRI were employed to develop assays in the BDG. These results were compared to those obtained with antigen capture enzyme linked immunosorbent assays (ELISAs). Four separate antigens were evaluated: Staphylococcus aureus enterotoxin B (SEB), ricin (RIC), Francisella tularensis (FT), and Clostridium botulinum toxin (BOT).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9001289
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0956-5663
pubmed:author	pubmed-author:AldrichJ LJL, pubmed-author:AllenS GSG, pubmed-author:BoiarskiA AAA, pubmed-author:Guz'A VAV, pubmed-author:JohnsonL HLH3rd, pubmed-author:LiangL TLT, pubmed-author:O'BrienTT, pubmed-author:PlummerA LAL
pubmed:issnType	Print
pubmed:volume	14
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	815-28
pubmed:dateRevised	2009-7-14
pubmed:meshHeading	pubmed-meshheading:10945456-Biological Warfare, pubmed-meshheading:10945456-Biosensing Techniques, pubmed-meshheading:10945456-Immunoassay, pubmed-meshheading:10945456-Sensitivity and Specificity
pubmed:year	2000
pubmed:articleTitle	The development of immunoassays to four biological threat agents in a bidiffractive grating biosensor.
pubmed:affiliation	Tetracore LLC, Rockville, MD 20850, USA. tobrien@tetracore.com
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, Non-P.H.S.