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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-9-14
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pubmed:abstractText |
Recent data indicated that disposition of oral digoxin is modulated by intestinal P-glycoprotein. The cardioselective beta-blocker talinolol has been described to be secreted by way of P-glycoprotein into the lumen of the gastrointestinal tract after oral and intravenous administration. We therefore hypothesized that coadministration of digoxin and talinolol may lead to a drug-drug interaction based on a competition for intestinal P-glycoprotein.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0009-9236
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10945310-Administration, Oral,
pubmed-meshheading:10945310-Adrenergic beta-Antagonists,
pubmed-meshheading:10945310-Adult,
pubmed-meshheading:10945310-Area Under Curve,
pubmed-meshheading:10945310-Biological Availability,
pubmed-meshheading:10945310-Cardiotonic Agents,
pubmed-meshheading:10945310-Chromatography, High Pressure Liquid,
pubmed-meshheading:10945310-Cross-Over Studies,
pubmed-meshheading:10945310-Digoxin,
pubmed-meshheading:10945310-Drug Therapy, Combination,
pubmed-meshheading:10945310-Female,
pubmed-meshheading:10945310-Fluorescence Polarization Immunoassay,
pubmed-meshheading:10945310-Half-Life,
pubmed-meshheading:10945310-Humans,
pubmed-meshheading:10945310-Infusions, Intravenous,
pubmed-meshheading:10945310-Intestinal Absorption,
pubmed-meshheading:10945310-Male,
pubmed-meshheading:10945310-P-Glycoprotein,
pubmed-meshheading:10945310-Propanolamines,
pubmed-meshheading:10945310-Reference Values,
pubmed-meshheading:10945310-Time Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein.
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pubmed:affiliation |
Division of Clinical Pharmacology, Institute of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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