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| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C1156210 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C1335840 | lld:lifeskim |
| pubmed-article:10943845 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:10943845 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10943845 | pubmed:dateCreated | 2000-9-14 | lld:pubmed |
| pubmed-article:10943845 | pubmed:abstractText | Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast and ovarian cancers. Using a combination of affinity- and conventional chromatographic techniques, we have isolated a predominant form of a multiprotein BRCA1-containing complex from human cells displaying chromatin-remodeling activity. Mass spectrometric sequencing of components of this complex indicated that BRCA1 is associated with a SWI/SNF-related complex. We show that BRCA1 can directly interact with the BRG1 subunit of the SWI/SNF complex. Moreover, p53-mediated stimulation of transcription by BRCA1 was completely abrogated by either a dominant-negative mutant of BRG1 or the cancer-causing deletion in exon 11 of BRCA1. These findings reveal a direct function for BRCA1 in transcriptional control through modulation of chromatin structure. | lld:pubmed |
| pubmed-article:10943845 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10943845 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10943845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10943845 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:10943845 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:WantDD | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:WuY VYV | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:WangLL | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:MatzR JRJ | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:KashanchiFF | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:ShiekhattarRR | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:BocharD ADA | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:BeniyaHH | lld:pubmed |
| pubmed-article:10943845 | pubmed:author | pubmed-author:KinevAA | lld:pubmed |
| pubmed-article:10943845 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10943845 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10943845 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:10943845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10943845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10943845 | pubmed:pagination | 257-65 | lld:pubmed |
| pubmed-article:10943845 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10943845 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10943845 | pubmed:articleTitle | BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. | lld:pubmed |
| pubmed-article:10943845 | pubmed:affiliation | The Wistar Institute, Philadelphia, Pennsylvania 19104, USA. | lld:pubmed |
| pubmed-article:10943845 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10943845 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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