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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-9-14
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pubmed:abstractText |
Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast and ovarian cancers. Using a combination of affinity- and conventional chromatographic techniques, we have isolated a predominant form of a multiprotein BRCA1-containing complex from human cells displaying chromatin-remodeling activity. Mass spectrometric sequencing of components of this complex indicated that BRCA1 is associated with a SWI/SNF-related complex. We show that BRCA1 can directly interact with the BRG1 subunit of the SWI/SNF complex. Moreover, p53-mediated stimulation of transcription by BRCA1 was completely abrogated by either a dominant-negative mutant of BRG1 or the cancer-causing deletion in exon 11 of BRCA1. These findings reveal a direct function for BRCA1 in transcriptional control through modulation of chromatin structure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BRCA1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCC2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-65
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10943845-BRCA1 Protein,
pubmed-meshheading:10943845-Breast Neoplasms,
pubmed-meshheading:10943845-Chromatin,
pubmed-meshheading:10943845-Chromatography, Affinity,
pubmed-meshheading:10943845-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:10943845-DNA Helicases,
pubmed-meshheading:10943845-DNA-Binding Proteins,
pubmed-meshheading:10943845-Female,
pubmed-meshheading:10943845-HeLa Cells,
pubmed-meshheading:10943845-Humans,
pubmed-meshheading:10943845-Nuclear Proteins,
pubmed-meshheading:10943845-Transcription Factors,
pubmed-meshheading:10943845-Transcriptional Activation
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pubmed:year |
2000
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pubmed:articleTitle |
BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer.
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pubmed:affiliation |
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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