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rdf:type |
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lifeskim:mentions |
umls-concept:C0005854,
umls-concept:C0034693,
umls-concept:C0063340,
umls-concept:C0175677,
umls-concept:C0449468,
umls-concept:C0598695,
umls-concept:C0599946,
umls-concept:C0699900,
umls-concept:C0876926,
umls-concept:C1517004,
umls-concept:C1527311
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pubmed:issue |
2
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pubmed:dateCreated |
2000-11-20
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pubmed:abstractText |
Traumatic brain injury (TBI) has been shown to induce a significant change in polyamine metabolism. Polyamines and polyamine-dependent calcium influx play an important role in mediating the effects of excitotoxic amino acids at the N-methyl-D-aspartate (NMDA) receptor site. We studied the effects of ifenprodil, known as a noncompetitive inhibitor of polyamine sites at the NMDA receptor, on brain edema formation, blood-brain barrier breakdown, and volume of injury after TBI.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
399-404; discussion 404-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10942013-Animals,
pubmed-meshheading:10942013-Blood-Brain Barrier,
pubmed-meshheading:10942013-Body Water,
pubmed-meshheading:10942013-Brain,
pubmed-meshheading:10942013-Brain Edema,
pubmed-meshheading:10942013-Brain Injuries,
pubmed-meshheading:10942013-Capillary Permeability,
pubmed-meshheading:10942013-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10942013-Male,
pubmed-meshheading:10942013-Piperidines,
pubmed-meshheading:10942013-Polyamines,
pubmed-meshheading:10942013-Rats,
pubmed-meshheading:10942013-Rats, Sprague-Dawley,
pubmed-meshheading:10942013-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
2000
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pubmed:articleTitle |
Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats.
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pubmed:affiliation |
Department of Neurological Surgery, University of Wisconsin, Madison, USA.
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pubmed:publicationType |
Journal Article
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