10941183

Source:http://linkedlifedata.com/resource/pubmed/id/10941183

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020179, umls-concept:C0040649
pubmed:issue	9
pubmed:dateCreated	2000-10-19
pubmed:abstractText	Although the gene responsible for Huntington's disease was discovered in 1993, the pathogenic mechanisms by which mutant huntingtin causes neuronal dysfunction and death remain unclear. However, increasing evidence suggests that mutant huntingtin disrupts the normal transcriptional program of susceptible neurons. Thus, transcriptional dysregulation might be an important pathogenic mechanism in Huntington's disease.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/NS 01916, http://linkedlifedata.com/resource/pubmed/grant/NS 38106
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7808616
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0166-2236
pubmed:author	pubmed-author:ObaM SMS
pubmed:issnType	Print
pubmed:volume	23
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	387-92
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:10941183-Humans, pubmed-meshheading:10941183-Huntington Disease, pubmed-meshheading:10941183-Transcription, Genetic
pubmed:year	2000
pubmed:articleTitle	Transcriptional dysregulation in Huntington's disease.
pubmed:affiliation	Dept. of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't