Source:http://linkedlifedata.com/resource/pubmed/id/10939330
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2000-8-28
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| pubmed:abstractText |
Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I describe a timing-based, associative form of long-term potentiation and depression (LTP/LTD) at this synapse in S1. LTP occurred when excitatory postsynaptic potentials (EPSPs) led single postsynaptic action potentials (APs) within a narrow temporal window, and LTD occurred when APs led EPSPs within a significantly broader window. This long LTD window is unusual among timing-based learning rules and causes EPSPs that are uncorrelated with postsynaptic APs to become depressed. This behavior suggests a simple model for depression of deprived sensory responses in S1 and V1.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0896-6273
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
45-56
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10939330-2-Amino-5-phosphonovalerate,
pubmed-meshheading:10939330-Animals,
pubmed-meshheading:10939330-Electric Stimulation,
pubmed-meshheading:10939330-Electrophysiology,
pubmed-meshheading:10939330-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10939330-Excitatory Postsynaptic Potentials,
pubmed-meshheading:10939330-Long-Term Potentiation,
pubmed-meshheading:10939330-Membrane Potentials,
pubmed-meshheading:10939330-Neuronal Plasticity,
pubmed-meshheading:10939330-Patch-Clamp Techniques,
pubmed-meshheading:10939330-Pyramidal Cells,
pubmed-meshheading:10939330-Rats,
pubmed-meshheading:10939330-Rats, Long-Evans,
pubmed-meshheading:10939330-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10939330-Somatosensory Cortex,
pubmed-meshheading:10939330-Synapses,
pubmed-meshheading:10939330-Vibrissae,
pubmed-meshheading:10939330-Vision, Monocular
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| pubmed:year |
2000
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| pubmed:articleTitle |
Timing-based LTP and LTD at vertical inputs to layer II/III pyramidal cells in rat barrel cortex.
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| pubmed:affiliation |
Neural Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. dfeldman@codon.nih.gov
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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